Analysis Tools
nervous system
| N |
• despite known endogenous gene expression in selected regions of adult wild-type brain, homozygotes show no significant changes in histology and neuronal density of the olfactory bulb, hippocampus CA1 and CA3 regions, or cerebellum relative to wild-type mice
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• in response to a submaximal stimulation protocol (100 Hz/0.2 sec), hippocampal CA1 slices from adult homozygotes exhibit a lowered threshold for LTP induction, whereas wild-type slices display only
short-term potentiation (STP) induction
• however, baseline excitatory synaptic transmission in the CA1 region appears unaffected, and addition of exogenous protein reverts the electrophysiological phenotype to that of wild-type controls such that only STP is induced
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• although modulation of synaptic efficacy by consecutive stimuli appears unaffected, the level of PPF is significantly elevated in mutant hippocampal CA1 slices at 60 min after LTP induction, in contrast to wild-type control slices where PPF remains unchanged
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behavior/neurological
| N |
• adult homozygotes are healthy and overtly normal with no significant differences in home cage behavior, balance, grip strength, exploratory behavior, or nociception relative to wild-type control mice
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reproductive system
| N |
• although dominant negative mutations have been reported to result in breeding problems in male mice, homozygotes are fertile and breed normally
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