Ptn^tm1Rau
Targeted Allele Detail

Summary

• Symbol: Ptn^tm1Rau
• Name: pleiotrophin; targeted mutation 1, Heikki Rauvala
• MGI ID: MGI:2183157
• Synonyms: HB-GAM -, HB-GAM^2-4neo, Ptn^-
• Gene: Ptn Location: Chr6:36691863-36787114 bp, - strand Genetic Position: Chr6, 15.48 cM
• Alliance: Ptn^tm1Rau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70253
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a neomycin selection cassette. Transcript was undetected via an RNA protection assay of RNA isolated from the brains of homozygous mutant mice. (J:70253)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptn Mutation: 14 strains or lines available

References

• Original: J:70253 Amet LE, et al., Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol Cell Neurosci. 2001 Jun;17(6):1014-24
• All: 22 reference(s)