Analysis Tools
skeleton
| N |
• despite osteosclerosis in adult mice, bone mineralization is normal
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• at P154, the resorption surface is reduced 21% in cortical bone, and 9% in trabecular bone compared to in wild-type mice
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• wider with delayed secondary centers of ossification at P21, P56, and to a lesser extent at P154
• at P21, the reserve zone is enlarged while the hypertrophic zone is narrower than in wild-type mice
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• delayed endochondral ossification: decrease in secondary ossification center size, increase in reserve zone width and decrease in hypertrophic zone at age P21
|
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• at age P21
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short tibia
(
J:120899
)
|
• up to 7% shorter between P21 and P56
|
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• delayed endochondral ossification: decrease in secondary ossification center size, increase in reserve zone width and decrease in hypertrophic zone at age P21
|
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• at age P21
|
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• at P21, calcified bone is decreased compared to in wild-type mice
|
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• 13% at P154
|
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• in vertebrae at age P21
• normal in long bones at age P21
|
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• 30% at P21
|
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• in juvenile mice, the bone volume fraction and number of trabeculae are decreased compared to in wild-type mice
• at P154, trabecular bone mass is increased with increased connectivity and plate-like morphology compared to in wild-type mice
• trabecular bone volume fraction is increased 1.8-fold compared to in wild-type mice
|
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• at P154
|
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• at age P21
|
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• in adult mice
|
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• chondrocytes treated with T3 and/or BMP2 exhibit lower alkaline phosphatase activity compared with similarly treated wild-type cells
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homeostasis/metabolism
| N |
• normal hypoglycemic effect of active thyroid hormone (T3) injection
|
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• at P56 but not P21 or P154
(J:120899)
|
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• enterocytes show a moderate decrease in lactase and sucrase enzyme activity
|
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• at P154, mice exhibit thinning of trabecular bone volume fraction following treatment with T4 unlike similarly treated wild-type mice
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cardiovascular system
|
• time to peak tension and time to 50% relaxation are prolonged compared to in wild-type mice
|
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• QRS duration is increased compared to in wild-type mice
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digestive/alimentary system
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• decrease in thickness of the mucosa
|
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• decrease in the number of goblet cells in the ileum
|
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• reduction in villus height that results from a decrease in the number of epithelial cells per crypt-villus axis
|
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• enterocytes show a moderate decrease in lactase and sucrase enzyme activity
|
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• proliferation is impaired but apparently normal differentiation; number of proliferating epithelial cells per crypt is reduced in the distal small intestine
• administration of T3 to induce hyperthyroidism, does not stimulate proliferation of crypt cells as in wild-type, despite higher levels of serum T3
|
muscle
|
• time to peak tension and time to 50% relaxation are prolonged compared to in wild-type mice
|
endocrine/exocrine glands
|
• mice exhibit skeletal hypothyrodism
|
growth/size/body
|
• at P21, P56, and P70
|
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• delayed linear growth at age P21
|
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• until P56
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hematopoietic system
|
• 13% at P154
|
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• at P154, the resorption surface is reduced 21% in cortical bone, and 9% in trabecular bone compared to in wild-type mice
|
immune system
|
• 13% at P154
|
|
• at P154, the resorption surface is reduced 21% in cortical bone, and 9% in trabecular bone compared to in wild-type mice
|
limbs/digits/tail
short tibia
(
J:120899
)
|
• up to 7% shorter between P21 and P56
|
short limbs
(
J:120899
)
|
• at P21
|
short tail
(
J:120899
)
|
• up to 17% shorter between P21 and P56
|
cellular
|
• decrease in the number of goblet cells in the ileum
|
|
• proliferation is impaired but apparently normal differentiation; number of proliferating epithelial cells per crypt is reduced in the distal small intestine
• administration of T3 to induce hyperthyroidism, does not stimulate proliferation of crypt cells as in wild-type, despite higher levels of serum T3
|
