Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Day mutation
(0 available);
any
Il21r mutation
(41 available)
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immune system
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• mice display a marked reduction in parasite-specific IgG1 after percutanous infection with S. mansoni cercariae
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• mice display a marked reduction in parasite-specific IgG2b after percutanous infection with S. mansoni cercariae
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• the Th2 response to infection with S. mansoni eggs is suppressed in these mice
• expression of Il21, Il4 and Il13 genes is significantly reduced in the lungs after infection compared to controls
• there is a more rapid resolution of granuloma formation in the lungs after infection which is indicative of a reduced Th2 response
• Th2 responses to Nippostrongylus brasiliensis infection are also reduced
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• expression of Il21, Il4 and Il13 genes is significantly reduced in the lungs after infection with S. mansoni eggs compared to controls
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• expression of Il21, Il4 and Il13 genes is significantly reduced in the lungs after infection with S. mansoni eggs compared to controls
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• expression of Il21, Il4 and Il13 genes is significantly reduced in the lungs after infection with S. mansoni eggs compared to controls
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• reduced Th2 responses to S. mansoni leads to quicker resolution of granulosomas in the lungs and reduced fibrosis of the lungs
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hematopoietic system
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• mice display a marked reduction in parasite-specific IgG1 after percutanous infection with S. mansoni cercariae
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• mice display a marked reduction in parasite-specific IgG2b after percutanous infection with S. mansoni cercariae
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• the Th2 response to infection with S. mansoni eggs is suppressed in these mice
• expression of Il21, Il4 and Il13 genes is significantly reduced in the lungs after infection compared to controls
• there is a more rapid resolution of granuloma formation in the lungs after infection which is indicative of a reduced Th2 response
• Th2 responses to Nippostrongylus brasiliensis infection are also reduced
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Day mutation
(0 available);
any
Il21r mutation
(41 available)
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Impaired allergic skin inflammation and systemic response to epicutaneous sensitization in Il21rtm1Day/Il21rtm1Day mice
immune system
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• the frequency of Th17 cells induced from nave T cells by Tgf-beta + IL-6 incubation is half that of controls
(J:123352)
• IL-21 fails to differentiate nave T cells under Th2 polarizing conditions into IL-21 secreting effector T cells
(J:136955)
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• the fraction of CD4+CD44+IL-17+ T cells is severely reduced compared to controls
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• levels of OVA-specific IgE are severely diminished compared to controls after immunization through the skin
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• IgE levels are increased 3-fold
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• IgG1 levels are decreased 3-fold
(J:76043)
• mice fail to make OVA-specific IgG1 in response to immunization through the skin
(J:144708)
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• mice fail to make OVA-specific IgG2a in response to immunization through the skin
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• IgG2b levels are decreased 2-fold
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• IL-21 fails to inhibit IL-15-mediated expansion of NK cells as it does with wild-type NK cells
• IL-21 fails to enhance IL-12 mediated secretion of IFN-gamma by activated NK cells
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• IL-21 fails to enhance cytolytic activity of activated NK cells as it does with wild-type NK cells
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• IL-21 fails to enhance IFN-gamma secretion mediated by TCR stimulation in the presence of IL-2 or IL-15
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• IL-21 fails to enhance cytolytic activity of T cells in response to alloantigen
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• IL-21 does not enhance alloantigen stimulation of T cells
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• thymocytes fail to respond to sub-optimal doses of CD3 and IL-21
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• IL-21 fails to inhibit IL-15-mediated expansion of memory CD8+ T cells as it does with wild-type NK cells
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• myeloid cells have defects in migration to draining lymph nodes after activation in the skin
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• Langerhans cells have defects in migration to draining lymph nodes after activation in the skin
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• plasmacytoid cells have defects in migration to draining lymph nodes after activation in the skin
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• mice are resistant to atopic dermatitis induced by OVA sensitization on skin stripped of hair
• mice also mount a significantly diminished cutaneous hypersensitivity response to skin painting with the hapten oxazolone
• mice also fail to mount systemic response to OVA antigen when sensitized through the skin as evidence by lack of cytokine production of splenocytes to OVA
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• splenocytes from mice sensitized to OVA through the skin fail to produce IFN-gamma upon OVA stimulation
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• IL-21 fails to enhance IL-12 mediated secretion of IFN-gamma by activated NK cells
(J:76043)
• IL-21 fails to enhance IFN-gamma secretion mediated by TCR stimulation in the presence of IL-2 or IL-15
(J:76043)
• more IFN-gamma is secreted when T cells from OVA-challenged mice are presented OVA peptide in vitro
(J:123352)
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• splenocytes from mice sensitized to OVA through the skin fail to produce IL-13 upon OVA stimulation
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• less IL-17 is secreted when T cells from OVA-challenged mice are presented OVA peptide in vitro
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• splenocytes from mice sensitized to OVA through the skin fail to produce IL-4 upon OVA stimulation
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hematopoietic system
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• the frequency of Th17 cells induced from nave T cells by Tgf-beta + IL-6 incubation is half that of controls
(J:123352)
• IL-21 fails to differentiate nave T cells under Th2 polarizing conditions into IL-21 secreting effector T cells
(J:136955)
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• the fraction of CD4+CD44+IL-17+ T cells is severely reduced compared to controls
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• levels of OVA-specific IgE are severely diminished compared to controls after immunization through the skin
|
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• IgE levels are increased 3-fold
|
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• IgG1 levels are decreased 3-fold
(J:76043)
• mice fail to make OVA-specific IgG1 in response to immunization through the skin
(J:144708)
|
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• mice fail to make OVA-specific IgG2a in response to immunization through the skin
|
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• IgG2b levels are decreased 2-fold
|
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• IL-21 fails to inhibit IL-15-mediated expansion of NK cells as it does with wild-type NK cells
• IL-21 fails to enhance IL-12 mediated secretion of IFN-gamma by activated NK cells
|
|
• IL-21 fails to enhance cytolytic activity of activated NK cells as it does with wild-type NK cells
|
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• IL-21 fails to enhance IFN-gamma secretion mediated by TCR stimulation in the presence of IL-2 or IL-15
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• IL-21 fails to enhance cytolytic activity of T cells in response to alloantigen
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• IL-21 does not enhance alloantigen stimulation of T cells
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• thymocytes fail to respond to sub-optimal doses of CD3 and IL-21
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• IL-21 fails to inhibit IL-15-mediated expansion of memory CD8+ T cells as it does with wild-type NK cells
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endocrine/exocrine glands
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• thymocytes fail to respond to sub-optimal doses of CD3 and IL-21
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