Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdctm1Nagy mutation
(0 available);
any
Hdc mutation
(50 available)
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behavior/neurological
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• male null animals show an age-dependent impaired spatial memory retention compared to age-matched controls
(J:105032)
• females show impairments in spatial learning and memory in the water-maze test compared to age-matched controls
(J:106034)
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• female null animals show enhanced emotional memory retention in passive avoidance training compared to wild-type
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• male null mice spend less time exploring than control mice; 3-5 month old null mice show reduced levels of novel object recognition than aged-matched controls or older null animals and age-matched controls
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• young male null mice show enhanced spatial learning in water-maze tests compared to age-matched controls
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• 3-5 month old male null mice show more anxiety-like behavior and move less than age-matched wild-type mice assessed by time spent in the center in an open field test; 12-14 month old mice null mice show increased anxiety-like responses also, but these are somewhat lower than the response of young null animals
(J:105032)
• in a light-dark test, male null mice move less and show more anxiety-like behavior than wild-type (as measured by increased time spent in the dark); older mice show reduced anxiety-like behavior than young ones
(J:105032)
• 3-5 month old female null mice show more anxiety-like behavior and move less than age-matched wild-type mice assessed by time spent in the center in an open field test; 12-14 month old mice null mice show similar increased anxiety-like responses
(J:106034)
• in a light-dark test, young and older female null mice move less and show more anxiety-like behavior than wild-type (as measured by increased time spent in the dark)
(J:106034)
• in an elevated plus-maze, older null females move less and show less total maze-arm entries than age matched controls
(J:106034)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdctm1Nagy mutation
(0 available);
any
Hdc mutation
(50 available)
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behavior/neurological
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N |
• mice show normal baseline locomotion, exploratory rearing, and center occupancy in the open field, and no evident spontaneous motor stereotypies or altered anxiety in the elevated plus maze or in the open field
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• locomotor activation is attenuated after amphetamine administration and mutants become immobile after a high dose of amphetamine
• mutants show increased motor stereotypies compared to controls after amphetamine administration, consisting of repetitive focused sniffing and orofacial movements
• pretreatment with haloperidol, a dopamine D2 receptor antagonist, attenuates the stereotypies induced by amphetamine
• mice infused with histamine intracerebroventricularly immediately before administration of amphetamine show delayed and reduced amplitude of stereotypy
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• mutants exhibit less paw-licking behavior (correlated with lowered pain sensitivity) in mutants compared with wild-type in response to subcutaneous injection of capsaicin or formalin
• intrathecal injection of histamine shortened the latency of the tail-flick test in null mice compared to wild-type; i.t. injection of a tachykinin NK1 receptor antagonist significantly inhibited histamine-related nociceptive behaviors in null mice
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• the latency to respond to tail pressure is significantly longer in mutants compared to wild-type
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• in hot-late, tail-flick and paw-withdrawal tests, the latency to respond to thermal stimuli is significantly prolongedin mutants compared to wild-type
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homeostasis/metabolism
immune system
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• mutant mast cells show pale and sparse granules compared to wild-type cells when stained with toluidine blue
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• numbers of mast cells in examined mesenterial membrane preparations from mutants are decreased by 55% compared to wild-type; numbers of mast cells in mutants are decreased in peritoneal cell suspensions as well
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• tissue histamine levels is almost zero in various organs except for the brain; mast cells in mutants have reduced granular content
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• the amount of granular protease in mast cells is decreased in mutants
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nervous system
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• mice exhibit higher dopamine D2 and D3 receptor density in the substantia nigra than controls
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• striatal histamine concentrations are reduced
• mice exhibit a reduction in dopamine D2 and D3 receptor density in the dorsal striatum
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• mice exhibit a deficit in auditory PPI at three prepulse intensities
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hematopoietic system
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• mutant mast cells show pale and sparse granules compared to wild-type cells when stained with toluidine blue
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• numbers of mast cells in examined mesenterial membrane preparations from mutants are decreased by 55% compared to wild-type; numbers of mast cells in mutants are decreased in peritoneal cell suspensions as well
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• tissue histamine levels is almost zero in various organs except for the brain; mast cells in mutants have reduced granular content
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• the amount of granular protease in mast cells is decreased in mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdctm1Nagy mutation
(0 available);
any
Hdc mutation
(50 available)
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growth/size/body
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• males over 3 weeks of age are dramatically overweight compared with wild-type males
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• up to 10 weeks of age, weights of male nulls are indistinguishable from wild-type males; after 16 weeks, nulls weigh 13 % more than controlx and the difference increases with age
• during a 7 day test period, male nulls aged 13 weeks gained more weight and had a higher caloric efficiency than wild-type controls
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homeostasis/metabolism
adipose tissue
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• mutant males show a selective increase of the interscapular brown adipose tissue (BAT) fat pads
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• mutant males show a selective increase of the epididymal white adipose tissue (WAT) fat pads
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• the average size of epididymal WAT adipocytes is larger in null males
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• males have increased size of epididymal fat pads
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• males have increased size of interscapular fat pads
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nervous system
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• brains of null animals have no detectable histamine-containing neurons and fibers
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Allelic
Composition |
Hdctm1Nagy/Hdc+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdctm1Nagy mutation
(0 available);
any
Hdc mutation
(50 available)
|
|
|
behavior/neurological
|
N |
• mice show normal baseline locomotion, exploratory rearing, and center occupancy in the open field, and no evident spontaneous motor stereotypies
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|
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• locomotor activation is attenuated after amphetamine administration
• mutants show increased motor stereotypies compared to controls after a high dose of amphetamine administration, consisting of repetitive focused sniffing and orofacial movements
• pretreatment with haloperidol, a dopamine D2 receptor antagonist, eliminates the stereotypies induced by amphetamine
• mice infused with histamine intracerebroventricularly immediately before administration of amphetamine show delayed and reduced amplitude of stereotypy
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nervous system
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• mice exhibit higher dopamine D2 and D3 receptor density in the substantia nigra than controls
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• mice exhibit a reduction in dopamine D2 and D3 receptor density in the dorsal striatum
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• mice exhibit a deficit in auditory PPI at three prepulse intensities
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Analysis Tools