Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ungtm1Tld mutation
(0 available);
any
Ung mutation
(23 available)
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normal phenotype
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• no overt phenotype up to one year; fertile and developed normally
• tumor free until 12 - 18 months
• detailed histopathology of male and female mice at 1 year showed no gross abnormalities
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ungtm1Tld mutation
(0 available);
any
Ung mutation
(23 available)
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cellular
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• mouse embryonic fibroblasts exhibit increased susceptibility to 5-hydroxymethyluridine and 5-fluorouracil toxicity compared with wild-type cells
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• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells
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hematopoietic system
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• reduced IgG1 class switch recombination
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• mice exhibit a marginal increase in germinal center B cell mutation frequency compared with wild-type mice
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homeostasis/metabolism
immune system
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• reduced IgG1 class switch recombination
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• mice exhibit a marginal increase in germinal center B cell mutation frequency compared with wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ungtm1Tld mutation
(0 available);
any
Ung mutation
(23 available)
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mortality/aging
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• increased mortality after 18 months of age, with decreased median life span compared to controls
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neoplasm
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• palpable in spleen and mesenteric lymph nodes of 12% of the mice after 18 months of age
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hematopoietic system
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• apparent after 18 months of age
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• apparent after 18 months of age
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• apparent after 18 months of age
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• altered isotype balance; class switching after LPS stimulation was diminished, but not as a result of lack of B cell proliferation
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• altered isotype balance
• class switching after LPS stimulation was diminished, but not as a result of lack of B cell prolferation
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immune system
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• apparent after 18 months of age
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• apparent after 18 months of age
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• apparent after 18 months of age
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• altered isotype balance; class switching after LPS stimulation was diminished, but not as a result of lack of B cell proliferation
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• altered isotype balance
• class switching after LPS stimulation was diminished, but not as a result of lack of B cell prolferation
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• apparent after 18 months of age
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• apparent after 18 months of age
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endocrine/exocrine glands
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• apparent after 18 months of age
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growth/size/body
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• apparent after 18 months of age
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• apparent after 18 months of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcnatm1Jcbs mutation
(0 available);
any
Pcna mutation
(16 available)
Ungtm1Tld mutation
(0 available);
any
Ung mutation
(23 available)
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hematopoietic system
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• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Pcnatm1Jcbs homozygotes
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immune system
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• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Pcnatm1Jcbs homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smug1tm1a(EUCOMM)Hmgu mutation
(0 available);
any
Smug1 mutation
(14 available)
Ungtm1Tld mutation
(0 available);
any
Ung mutation
(23 available)
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mortality/aging
N |
• mice exhibit normal life expectancy
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cellular
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• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells
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• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation
(1 available);
any
Msh2 mutation
(95 available)
Smug1tm1a(EUCOMM)Hmgu mutation
(0 available);
any
Smug1 mutation
(14 available)
Ungtm1Tld mutation
(0 available);
any
Ung mutation
(23 available)
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mortality/aging
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• mean life expectancy is 107 days compared with 223 days for Msh2tm1Htr homozygotes
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• fewer than expected mice are identified at weaning
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neoplasm
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• in 4 of 5 mice with tumors
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smug1tm1a(EUCOMM)Hmgu mutation
(0 available);
any
Smug1 mutation
(14 available)
Ungtm1Tld mutation
(0 available);
any
Ung mutation
(23 available)
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mortality/aging
N |
• mice exhibit normal life expectancy
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cellular
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• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells
|
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• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation
(1 available);
any
Msh2 mutation
(95 available)
Smug1tm1a(EUCOMM)Hmgu mutation
(0 available);
any
Smug1 mutation
(14 available)
Ungtm1Tld mutation
(0 available);
any
Ung mutation
(23 available)
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mortality/aging
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• mean life expectancy is 107 days compared with 223 days for Msh2tm1Htr homozygotes
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• fewer than expected mice are identified at weaning
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neoplasm
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• in 4 of 5 mice with tumors
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