All Phenotypes Gast<tm1Lcs> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gast^tm1Lcs/Gast^tm1Lcs	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:4821147
hm2	Gast^tm1Lcs/Gast^tm1Lcs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2672026
ht3	Gast^tm1Lcs/Gast⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3625151
cx4	Atp4b^tm1Ird/Atp4b^tm1Ird Gast^tm1Lcs/Gast^tm1Lcs	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc	MGI:3624965

Allelic Composition	Gast^tm1Lcs/Gast^tm1Lcs
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gast^tm1Lcs mutation (1 available); any Gast mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating unsaturated transferrin level ( J:142455 )

• at 4 weeks, transferrin saturation is reduced 0.76-fold compared with wild-type mice

abnormal iron homeostasis ( J:142455 )

• iron absorption in juvenile mice is increased 6-fold compared to in wild-type mice

• however, iron absorption at 10 weeks is normal

decreased circulating iron level ( J:142455 )

• however, iron levels at 10 weeks are normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:97527 )

• expanded surface mucus layer in the fundus

abnormal gastric gland morphology ( J:77780 )

abnormal gastric parietal cell morphology ( J:77780 , J:107860 )

• 23% reduction in parietal cells (J:77780)

• larger numbers of parietal cells recovered from mucosa relative to controls but size of cells reduced (J:107860)

• calcium levels in parietal cells significantly higher than in controls (J:107860)

increased stomach tumor incidence ( J:97527 )

• macroscopically visible tumors present in 60% of mice at 12 months of age

• tumors all in antral region

abnormal digestive system physiology ( J:97527 )

• increased levels of apoptosis in the fundus and significantly reduced apoptosis in the antrum

abnormal digestive secretion ( J:77780 , J:97527 )

• complete loss of gastric acid secretion (J:77780)

stomach inflammation ( J:97527 )

• increased inflammatory cell infiltration of the mucosa in the antrum

• increased levels of antral polymorphonuclear neutrophils and T cells

neoplasm

increased stomach tumor incidence ( J:97527 )

• macroscopically visible tumors present in 60% of mice at 12 months of age

• tumors all in antral region

immune system

stomach inflammation ( J:97527 )

• increased inflammatory cell infiltration of the mucosa in the antrum

• increased levels of antral polymorphonuclear neutrophils and T cells

endocrine/exocrine glands

abnormal gastric gland morphology ( J:77780 )

abnormal gastric parietal cell morphology ( J:77780 , J:107860 )

• 23% reduction in parietal cells (J:77780)

• larger numbers of parietal cells recovered from mucosa relative to controls but size of cells reduced (J:107860)

• calcium levels in parietal cells significantly higher than in controls (J:107860)

Allelic Composition	Gast^tm1Lcs/Gast⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gast^tm1Lcs mutation (1 available); any Gast mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal digestive secretion ( J:77780 )

• 2 fold reduction in gastrin in the stomach but plasma levels remain normal

Allelic Composition	Atp4b^tm1Ird/Atp4b^tm1Ird Gast^tm1Lcs/Gast^tm1Lcs
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp4b^tm1Ird mutation (2 available); any Atp4b mutation (30 available)
Gast^tm1Lcs mutation (1 available); any Gast mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal stomach mucosa morphology ( J:108678 )

• hypertrophy of the gastric mucosa is eliminated in the double homozygote

abnormal gastric gland morphology ( J:108678 )

• moderate increase in apoptotic cells and in immature cell numbers

abnormal gastric chief cell morphology ( J:108678 )

• near total absence of zymogenic cells

abnormal gastric parietal cell morphology ( J:108678 )

• sightly decreased number of parietal cells about half of which are vacuolated and half are normal

endocrine/exocrine glands

abnormal gastric gland morphology ( J:108678 )

• moderate increase in apoptotic cells and in immature cell numbers

abnormal gastric chief cell morphology ( J:108678 )

• near total absence of zymogenic cells

abnormal gastric parietal cell morphology ( J:108678 )

• sightly decreased number of parietal cells about half of which are vacuolated and half are normal

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