Phenotypes associated with this allele

• Allele Symbol: Npy^tm1Rpa
• Allele Name: targeted mutation 1, Richard D Palmiter
• Allele ID: MGI:2182113
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npy^tm1Rpa/Npy^tm1Rpa	involves: 129S7/SvEvBrd	MGI:3046869
cx2	Agrp^tm1Sqn/Agrp^tm1Sqn Npy^tm1Rpa/Npy^tm1Rpa	involves: 129S7/SvEvBrd	MGI:2654840

Genotype
MGI:3046869

hm1

• Allelic Composition: Npy^tm1Rpa/Npy^tm1Rpa
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:33261 )

• pentylenetrazole (PTZ) treatment at 50 or 60 mg/kg induced convulsions in 80% of mutant mice compared to 33% of controls

• convulsions in the mutant mice were also scored as more severe

sporadic seizures ( J:33261 )

• mice exhibited occasional mild seizures at 6-8 weeks of age, with decreased frequency until 9 weeks and were not seen thereafter; seizures consisted of jerking of the head and body, tail extension and vocalization

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:33261 )

N • no defects were observed in food intake, body weight and adiposity

N • normal glucose homeostasis was also noted

N • responses to food deprivation was similar to controls

nervous system

increased susceptibility to pharmacologically induced seizures ( J:33261 )

• pentylenetrazole (PTZ) treatment at 50 or 60 mg/kg induced convulsions in 80% of mutant mice compared to 33% of controls

• convulsions in the mutant mice were also scored as more severe

sporadic seizures ( J:33261 )

• mice exhibited occasional mild seizures at 6-8 weeks of age, with decreased frequency until 9 weeks and were not seen thereafter; seizures consisted of jerking of the head and body, tail extension and vocalization

Genotype
MGI:2654840

cx2

• Allelic Composition: Agrp^tm1Sqn/Agrp^tm1Sqn; Npy^tm1Rpa/Npy^tm1Rpa
• Genetic Background: involves: 129S7/SvEvBrd

normal phenotype

no abnormal phenotype detected ( J:78034 )

• mice exhibit no obvious deficiency in body weight or feeding behavior and respond to starvation in a similar manner to controls