All Phenotypes Del(3Cd1d2-Cd1d1)1Crw MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw	involves: 129S4/SvJae * C57BL/6	MGI:2661989
cx2	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tcra^Ln1Ogu/Tcra⁺	involves: 129/Sv * C57BL/6	MGI:4356165
cx3	Cd1d1^tm2Aben/Del(3Cd1d2-Cd1d1)1Crw	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5056353
cx4	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tg(TcraAV19AJ33)1Shima/0	involves: 129S4/SvJae * C57BL/6	MGI:3831164

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:174337 )

• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice

decreased NK T cell number ( J:39749 , J:76976 , J:112657 , J:174337 )

• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281 (J:39749)

• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested (J:76976)

• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver (J:112657)

• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice (J:174337)

abnormal NK T cell physiology ( J:112657 )

• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells

abnormal antigen presentation ( J:174337 )

• thymocytes exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

decreased interleukin-4 secretion ( J:39749 )

• mutants show impaired IL-4 production after stimulation with anti-CD3 antibodies, however they are able to generate antigen-specific Th2 responses

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:174337 )

• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice

decreased NK T cell number ( J:39749 , J:76976 , J:112657 , J:174337 )

• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281 (J:39749)

• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested (J:76976)

• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver (J:112657)

• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice (J:174337)

abnormal NK T cell physiology ( J:112657 )

• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells

Allelic Composition	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tcra^Ln1Ogu/Tcra⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)
Tcra^Ln1Ogu mutation (0 available); any Tcra mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell morphology ( J:152041 )

• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers

• immature iNKT cells that are CD24⁺CD44^dullNK1.1^- are very abundant in the thymus

hematopoietic system

abnormal NK T cell morphology ( J:152041 )

• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers

• immature iNKT cells that are CD24⁺CD44^dullNK1.1^- are very abundant in the thymus

Allelic Composition	Cd1d1^tm2Aben/Del(3Cd1d2-Cd1d1)1Crw
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm2Aben mutation (1 available); any Cd1d1 mutation (30 available)
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal antigen presentation ( J:174337 )

• peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

Allelic Composition	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tg(TcraAV19AJ33)1Shima/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal NK T cell morphology ( J:112657 )

• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain

• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time

• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells

immune system

abnormal NK T cell morphology ( J:112657 )

• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain

• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time

• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells

increased interleukin-10 secretion ( J:112657 )

• transgenic NK T cells isolated from these mice induce IL-10 secretion from CD19⁺ B cells and other NK T cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:112657 )

• the progression and development of MOG-induced EAE is suppressed in these mice compared to both wild-type and Cd1d1/Cd1d2^tm1Crw homozygotes

• mean severity score is 1.3 versus 3.3 in wild-type controls

• mice at day 15 post induction have 3-fold less infiltrating mononuclear cells in their spinal cord with a lower percentage of CD4⁺ T cells making up the infiltrate (6% of infiltrating cells vs 21% in littermate controls)

• memory T cells isolated from mice 10 days after disease induction produce less inflammatory cytokines (IFN-g, TNF, IL-2 and IL-17) and more IL-10

• mean day of onset is 14.3 compared to 13.6 for wild-type controls

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