Phenotypes associated with this allele

• Allele Symbol: Cd9^tm1Mek
• Allele Name: targeted mutation 1, Eisuke Mekada
• Allele ID: MGI:2181695
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd9^tm1Mek/Cd9^tm1Mek	involves: 129/Sv * C57BL/6	MGI:2672838
cx2	Cd81^tm1Tmiy/Cd81^tm1Tmiy Cd9^tm1Mek/Cd9^tm1Mek	involves: 129/Sv * C57BL/6	MGI:2672816

Genotype
MGI:2672838

hm1

• Allelic Composition: Cd9^tm1Mek/Cd9^tm1Mek
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:260669 )

♀ • eggs show reduced surface expression of IGSF8 (immunoglobulin superfamily, member 8) relative to wild-type eggs

female infertility ( J:59402 )

♀ • ovaries normal

♀ • about 2% of normal number of pups born

♀ • failure of eggs to fuse with sperm and form pronuclei

♀ • males have normal fertility

hematopoietic system

abnormal definitive hematopoiesis ( J:83795 )

• homozygotes display enhanced formation of multinucleated giant cells after stimulation

cellular

abnormal oocyte morphology ( J:260669 )

♀ • eggs show reduced surface expression of IGSF8 (immunoglobulin superfamily, member 8) relative to wild-type eggs

Genotype
MGI:2672816

cx2

• Allelic Composition: Cd81^tm1Tmiy/Cd81^tm1Tmiy; Cd9^tm1Mek/Cd9^tm1Mek
• Genetic Background: involves: 129/Sv * C57BL/6

growth/size/body

decreased body size ( J:83795 )

• mice are viable in spite of smaller body size

hematopoietic system

abnormal definitive hematopoiesis ( J:83795 )

increased osteoclast cell number ( J:83795 )

• 1.5X increase in osteoclast numbers

abnormal macrophage physiology ( J:83795 )

• spontaneous formation of multinucleated giant cells

immune system

increased osteoclast cell number ( J:83795 )

• 1.5X increase in osteoclast numbers

abnormal macrophage physiology ( J:83795 )

• spontaneous formation of multinucleated giant cells

respiratory system

abnormal pulmonary alveolus morphology ( J:83795 )

• alveolar airspace enlargement

skeleton

increased osteoclast cell number ( J:83795 )

• 1.5X increase in osteoclast numbers

decreased bone mineral density ( J:83795 )

abnormal skeleton development ( J:83795 )