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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacna1aTg-5J
tottering 5 Jackson
MGI:2181625
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cacna1aTg-5J/Cacna1aTg-5J B10.Cg-Cacna1aTg-5J MGI:3804052
hm2
 		Cacna1aTg-5J/Cacna1aTg-5J involves: BALB/cByJ * C57BL/10J MGI:3803743
ht3
 		Cacna1aTg-5J/Cacna1a+ B10.Cg-Cacna1aTg-5J MGI:3804050
cx4
 		Cacna1aTg-5J/Cacna1a+
Tg(Pvalb-EGFP)B20Zjh/? 		involves: BALB/cByJ * C57BL/6 * C57BL/10J MGI:3803746


Genotype
MGI:3804052
hm1
Allelic
Composition		 Cacna1aTg-5J/Cacna1aTg-5J
Genetic
Background		 B10.Cg-Cacna1aTg-5J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1aTg-5J mutation (1 available); any Cacna1a mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:137816 )
• Background Sensitivity: on the B10 genetic background, no homozygotes are produced from heterozygote x heterozygote matings




Genotype
MGI:3803743
hm2
Allelic
Composition		 Cacna1aTg-5J/Cacna1aTg-5J
Genetic
Background		 involves: BALB/cByJ * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1aTg-5J mutation (1 available); any Cacna1a mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:137816 )
• homozygotes do not live beyond 6 weeks of age
preweaning lethality, incomplete penetrance ( J:137816 )
• Background Sensitivity: only 3% of homozygotes are produced from heterozygote x heterozygote matings

behavior/neurological
ataxia ( J:137816 )
• homozygotes are severely ataxic

growth/size/body
decreased body size ( J:137816 )
• runted




Genotype
MGI:3804050
ht3
Allelic
Composition		 Cacna1aTg-5J/Cacna1a+
Genetic
Background		 B10.Cg-Cacna1aTg-5J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1aTg-5J mutation (1 available); any Cacna1a mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:137816 )
• gait is shaky and hindlimbs are splayed laterally from body

nervous system
abnormal Purkinje cell morphology ( J:137816 )
• Purkinje cell arbor is reduced in complexity and in overall dendritic mass
abnormal Purkinje cell dendrite morphology ( J:137816 )
• tips of distal dendrites have an abnormal serpentine-like appearance
• shafts of dendrites exhibit a thickening in the upper molecular layer
abnormal axon morphology ( J:137816 )
• axonal swelling is observed in Purkinje cells
abnormal nervous system electrophysiology ( J:137816 )
• calcium channel voltage activation and inactivation is shifted to lower voltages




Genotype
MGI:3803746
cx4
Allelic
Composition		 Cacna1aTg-5J/Cacna1a+
Tg(Pvalb-EGFP)B20Zjh/?
Genetic
Background		 involves: BALB/cByJ * C57BL/6 * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1aTg-5J mutation (1 available); any Cacna1a mutation (115 available)
Tg(Pvalb-EGFP)B20Zjh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell morphology ( J:137816 )
• GFP-stained Purkinje cells exhibit decreased branching
• primary branches have novel GFP-negative vacuoles that do not impede cytoplasmic flow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory