Analysis Tools
mortality/aging
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• at 4 weeks
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nervous system
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• the external granule cell layer persists longer than in wild-type mice
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• mice exhibit an increased in TH-immunoreactive neurons in the deep cortical layers compared to in wild-type mice indicative of a delay in development
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• mice exhibit abundant focal axonal swelling unlike in wild-type mice
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• mice exhibit sensitivity of excitatory postsynaptic potential to omega-CTx-GVIA blockage and 4-APP stimulation compared to in similarly treated wild-type mice
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• total current density of calcium ion channels is reduced compared to in wild-type mice
• omega-CTx-MVIIC-sensitive and P/Q currents of calcium ion channels are decreased compared to in wild-type mice
• calcium ion channel current density in Purkinje cells is decrease compared to in wild-type mice
• while P-type channel activity is eliminated, L-type and N-type calcium ion channel activity are increased compared to in wild-type mice
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behavior/neurological
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• older mice exhibit prolonged and less successful attempts at righting compared to in wild-type mice
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• after 10 days, mice exhibit lose of balance when walking and roll onto their backs unlike wild-type mice
• falling while walking worsens with age and by P20 mice cannot walk
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• after 10 days, mice exhibit lose of balance when walking that worsens with again and roll onto their backs unlike wild-type mice
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muscle
muscle spasm
(
J:59076
)
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• older mice exhibit extensor spasms of the hindlimbs during righting effort unlike in wild-type mice
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growth/size/body
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• at 4 weeks
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