Cacna1a^tm1Hssh
Targeted Allele Detail

Summary

• Symbol: Cacna1a^tm1Hssh
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; targeted mutation 1, Hee-Sup Shin
• MGI ID: MGI:2181384
• Synonyms: alpha1a^-, alpha-1A KO, alphaA1^-, Cca1A,-
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^tm1Hssh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59076
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was targeted by replacement of an exon and intron with a PGK-neo cassette via homologous recombination. Brains of homozygous mutant animals lacked gene expression as determined by Northern blot, RT-PCR analysis, and Western blot. (J:59076)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 115 strains or lines available

References

• Original: J:59076 Jun K, et al., Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15245-50
• All: 25 reference(s)