Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbtm1Jmk mutation
(1 available);
any
Ppp3cb mutation
(66 available)
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immune system
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• in response to stimulation, total splenocytes show reduced proliferation
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• in response to stimulation, total splenocytes show increased Il2 production compared to wild-type
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homeostasis/metabolism
muscle
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• the cross-sectional area of the soleus is decreased
• the cross-sectional area in the extensor digitorum longus is normal
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• the number of fibers is increased in the soleus
• the fiber number in the extensor digitorum longus is normal
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• the skeletal muscle exhibits less oxidative/slow fiber muscle type than wild-type
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growth/size/body
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• mice exhibit reduced body weight despite normal muscle weights for their size (27.0+/-1.0 g compared to 30.3+/-0.7 g in wild-type mice)
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hematopoietic system
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• in response to stimulation, total splenocytes show reduced proliferation
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cellular
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• in response to stimulation, total splenocytes show reduced proliferation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbtm1Jmk mutation
(1 available);
any
Ppp3cb mutation
(66 available)
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Cardiac histological analysis of wild type and Ppp3cbtm1Jmk/Ppp3cbtm1Jmk mice
cardiovascular system
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N |
• normal cardiovascular function
• normal fractional shortening
• normal heart rate
• normal mean arterial blood pressure
• normal angiotensin II-induced pressor response
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• 12% reduction in basal heart size, with trend toward smaller chamber dimensions, ventricular wall thickness, and septal wall thickness
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• inability to mount hypertrophic response to pressure overload, angiotensin II infusion, or isoproterenol infusion
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growth/size/body
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• male mice showed 10% reduction in body weight at 8 weeks of age
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hematopoietic system
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• in response to either CD3-activating antibodies or PMA/ionomycin
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• evident between 4 and 8 weeks of age
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• of total peripheral T cells
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• reduced numbers of CD3+, and CD4 and CD8 single positive T cells
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immune system
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• in response to either CD3-activating antibodies or PMA/ionomycin
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• evident between 4 and 8 weeks of age
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• of total peripheral T cells
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• reduced numbers of CD3+, and CD4 and CD8 single positive T cells
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homeostasis/metabolism
endocrine/exocrine glands
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• evident between 4 and 8 weeks of age
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cellular
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• in response to either CD3-activating antibodies or PMA/ionomycin
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behavior/neurological
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• mice show a significant increase in cumulative activity during light and dark conditions, even greater than that shown in Dscr1/Dscr1l1 knockouts
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immune system
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• in response to stimulation, total splenocytes show reduced proliferation
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• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
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• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
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• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
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• in response to stimulation, total splenocytes show increased Il2 production compared to wild-type
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hematopoietic system
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• in response to stimulation, total splenocytes show reduced proliferation
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• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
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• T cell development is compromised in triple knockouts compared to wild-type, single or double knockouts; a reduction in number in the spleen is observed
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• after CD3 stimulation, increased apoptosis of CD4+ T cells is observed
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cardiovascular system
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• cardiac function reveals partial protection from pressure overload stimulation decompensation induced by transverse aortic constriction compared to wild-type; cardiac hypertrophy is attenuated
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homeostasis/metabolism
cellular
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• in response to stimulation, total splenocytes show reduced proliferation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbtm1Jmk mutation
(1 available);
any
Ppp3cb mutation
(66 available)
Tg(Myh6-Mapk14*)1Jmol mutation
(1 available)
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cardiovascular system
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N |
• interstitial cell fibrosis is significantly attenuated compare with Tg(Myh6-Mapk14*)1Jmol mice
• at 2 months, mice show complete rescue in hypertrophic growth seen in Tg(Myh6-Mapk14*)1Jmol animals
• rescue of the chamber enlargement and reduced fractional shortening is also observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbtm1Jmk mutation
(1 available);
any
Ppp3cb mutation
(66 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation
(1 available)
Tg(Myh6-tTA)55Rbns mutation
(2 available)
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cardiovascular system
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• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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• less than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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• more so than in Ppp3cbtm1Jmk homozygotes and similar to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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muscle
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• more so than in Ppp3cbtm1Jmk homozygotes and similar to in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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growth/size/body
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• less than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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Analysis Tools