All Phenotypes Jun<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Jun⁺
wild type
MGI:2181274

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Jun^em1(IMPC)Mbp/Jun⁺	C57BL/6N-Jun^em1(IMPC)Mbp/MbpMmucd	MGI:6408457
cn2	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm4Wag/Jun⁺ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4867644
cn3	Isl1^tm1(cre)Sev/Isl1⁺ Jun^tm4Wag/Jun⁺	Not Specified	MGI:7562245

Allelic Composition	Jun^em1(IMPC)Mbp/Jun⁺
Genetic Background	C57BL/6N-Jun^em1(IMPC)Mbp/MbpMmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jun^em1(IMPC)Mbp mutation (1 available); any Jun mutation (12 available)

Data Sources

IMPC Data for Jun

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:211773 )

IMPC - UCD

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

IMPC - UCD

homeostasis/metabolism

edema ( J:211773 )

IMPC - UCD

immune system

abnormal lymph node morphology ( J:211773 )

IMPC - UCD

enlarged lymph nodes ( J:211773 )

IMPC - UCD

nervous system

increased prepulse inhibition ( J:211773 )

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - UCD

anophthalmia ( J:211773 )

IMPC - UCD

Allelic Composition	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm4Wag/Jun⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7^tm1.1Axbe mutation (4 available); any Fbxw7 mutation (81 available)
Jun^tm4Wag mutation (0 available); any Jun mutation (12 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron apoptosis ( J:166928 )

• neurosphere apoptosis is decreased compared to in Fbxw7^tm1Axbe/Fbxw7^tm1Axbe Tg(Nes-cre)1Kln mice

abnormal tectum morphology ( J:166928 )

• the cellularity defect in the mantle layer of the midbrain tectum observed in Fbxw7^tm1Axbe/Fbxw7^tm1Axbe Tg(Nes-cre)1Kln mice is rescued

• the number of stem cells in the tectal ventricular zone is increased compared to in wild-type mice

cellular

abnormal neuron apoptosis ( J:166928 )

• neurosphere apoptosis is decreased compared to in Fbxw7^tm1Axbe/Fbxw7^tm1Axbe Tg(Nes-cre)1Kln mice

Allelic Composition	Isl1^tm1(cre)Sev/Isl1⁺ Jun^tm4Wag/Jun⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Sev mutation (1 available); any Isl1 mutation (37 available)
Jun^tm4Wag mutation (0 available); any Jun mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

interrupted aortic arch, type b ( J:199412 )

• at E14.5 to P0, a single embryo (1 of 22) shows IAA type B

• however, no other OFT or aortic arch abnormalities are observed

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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