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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Jak3+
wild type
MGI:2181270
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Jak3em1(IMPC)Mbp/Jak3+ C57BL/6N-Jak3em1(IMPC)Mbp/MbpMmucd MGI:6480485
ht2
 		Jak3tm1Tks/Jak3+ involves: 129P2/OlaHsd * C57BL/6 MGI:3579843
ht3
 		Jak3tm1Ljb/Jak3+ involves: 129S4/SvJae MGI:3769346
ht4
 		Jak3M1Pgrs/Jak3+ involves: C57BL/6J * C57BL/10J MGI:5468016


Genotype
MGI:6480485
ht1
Allelic
Composition		 Jak3em1(IMPC)Mbp/Jak3+
Genetic
Background		 C57BL/6N-Jak3em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3em1(IMPC)Mbp mutation (1 available); any Jak3 mutation (84 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:211773 )
IMPC - UCD

embryo

growth/size/body
enlarged spleen ( J:211773 )
IMPC - UCD

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - UCD

immune system
enlarged spleen ( J:211773 )
IMPC - UCD

nervous system

vision/eye
cataract ( J:211773 )
IMPC - UCD




Genotype
MGI:3579843
ht2
Allelic
Composition		 Jak3tm1Tks/Jak3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3tm1Tks mutation (0 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:31231 )
• proliferative response of 4-week old thymoctyes to the cytokines, IL-2, IL-4, or IL-7, was half of that from wildtype

hematopoietic system
abnormal leukocyte physiology ( J:31231 )
• proliferative response of 4-week old thymoctyes to the cytokines, IL-2, IL-4, or IL-7, was half of that from wildtype




Genotype
MGI:3769346
ht3
Allelic
Composition		 Jak3tm1Ljb/Jak3+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3tm1Ljb mutation (1 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte morphology ( J:56629 )
• slight increase in the number of cells classified as myeloid or premonocytic
decreased lymphocyte cell number ( J:56629 )
• lymphopenia is seen in peripheral and bone marrow smears
• at 6-12 months of age, lymphocyte numbers in whole blood suspensions are decreased
increased leukocyte cell number ( J:56629 )
• at 6-12 months of age, a profound increase in large granular cells is seen in the peripheral blood and spleen
• these large granular cells consist of 2 populations; cells of the neutrophilic lineage and cells of the monocytic lineage
increased neutrophil cell number ( J:56629 )
• significantly higher numbers of both segmented and band neutrophils
increased monocyte cell number ( J:56629 )
• at 6 - 12 months of age in the bone marrow and spleen

hematopoietic system
abnormal leukocyte morphology ( J:56629 )
• slight increase in the number of cells classified as myeloid or premonocytic
decreased lymphocyte cell number ( J:56629 )
• lymphopenia is seen in peripheral and bone marrow smears
• at 6-12 months of age, lymphocyte numbers in whole blood suspensions are decreased
increased leukocyte cell number ( J:56629 )
• at 6-12 months of age, a profound increase in large granular cells is seen in the peripheral blood and spleen
• these large granular cells consist of 2 populations; cells of the neutrophilic lineage and cells of the monocytic lineage
increased neutrophil cell number ( J:56629 )
• significantly higher numbers of both segmented and band neutrophils
increased monocyte cell number ( J:56629 )
• at 6 - 12 months of age in the bone marrow and spleen




Genotype
MGI:5468016
ht4
Allelic
Composition		 Jak3M1Pgrs/Jak3+
Genetic
Background		 involves: C57BL/6J * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3M1Pgrs mutation (0 available); any Jak3 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:185217 )
• half of mice are resistant lethality associated with cerebral malaria induced by infection with Plasmodium berghei ANKA-parasitized red blood cells compared with control mice mice

immune system
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:185217 )
• half of mice are resistant lethality associated with cerebral malaria induced by infection with Plasmodium berghei ANKA-parasitized red blood cells compared with control mice mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory