Phenotypes associated with this allele

• Allele Symbol: Ccr9^tm1.1Mal
• Allele Name: targeted mutation 1.1, Bernard Malissen
• Allele ID: MGI:2181004
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccr9^tm1.1Mal/Ccr9^tm1.1Mal	involves: 129S2/SvPas	MGI:3799632
hm2	Ccr9^tm1.1Mal/Ccr9^tm1.1Mal	involves: 129S2/SvPas * C57BL/6	MGI:3052995
cx3	Ccr9^tm1.1Mal/Ccr9^tm1.1Mal Tnf^tm2Gkl/Tnf^+	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:3799634

Genotype
MGI:3799632

hm1

• Allelic Composition: Ccr9^tm1.1Mal/Ccr9^tm1.1Mal
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell subpopulation ratio ( J:136944 )

• in the lamina propria of the intestine the proportion of CD8+ T cells is reduced and there is a relative increase in CD4+ T cells and B cells

abnormal gamma-delta T cell number ( J:136944 )

• increase in the relative percentage of gamma-delta T cells in the mesenteric lymph node

decreased gamma-delta intraepithelial T cell number ( J:136944 )

• decrease in the total number of intraepithelial lymphocytes primarily apparently due to a reduction in the number of gamma-delta intraepithelial lymphocytes

• only account for 20-30% of the total intraepeithelial lymphocyte T cell population

abnormal mesenteric lymph node morphology ( J:136944 )

• increase in the relative percentage of gamma-delta T cells

hematopoietic system

abnormal T cell subpopulation ratio ( J:136944 )

• in the lamina propria of the intestine the proportion of CD8+ T cells is reduced and there is a relative increase in CD4+ T cells and B cells

abnormal gamma-delta T cell number ( J:136944 )

• increase in the relative percentage of gamma-delta T cells in the mesenteric lymph node

decreased gamma-delta intraepithelial T cell number ( J:136944 )

• decrease in the total number of intraepithelial lymphocytes primarily apparently due to a reduction in the number of gamma-delta intraepithelial lymphocytes

• only account for 20-30% of the total intraepeithelial lymphocyte T cell population

Genotype
MGI:3052995

hm2

• Allelic Composition: Ccr9^tm1.1Mal/Ccr9^tm1.1Mal
• Genetic Background: involves: 129S2/SvPas * C57BL/6

hematopoietic system

decreased pro-B cell number ( J:72386 )

• fewer pre-pro B cells

• fewer CD4+ B220+ B cells in bone marrow, but numbers of mature B cells are not affected

abnormal T cell differentiation ( J:72386 )

• one day lag in the development of double positive cells in fetal thymus

abnormal leukocyte cell number ( J:72386 )

decreased T cell number ( J:72386 )

• 3-5 fold decrease in number of T cell receptor gamma/delta cells found in small intestine

• intraepithelial lymphocyte to epithelial cell ratio is decreased 2-fold in small intestine

decreased double-positive T cell number ( J:72386 )

• 3-fold fewer lymphoid cells from E14.5-E17.5, corrected by E18.5

• 15-20 fold fewer double positive cells at E16.5

increased T cell number ( J:72386 )

• 2-3 fold increase in peripheral T cell receptor gamma/delta cells found in lymph nodes and spleen

immune system

decreased pro-B cell number ( J:72386 )

• fewer pre-pro B cells

• fewer CD4+ B220+ B cells in bone marrow, but numbers of mature B cells are not affected

abnormal T cell differentiation ( J:72386 )

• one day lag in the development of double positive cells in fetal thymus

abnormal leukocyte cell number ( J:72386 )

decreased T cell number ( J:72386 )

• 3-5 fold decrease in number of T cell receptor gamma/delta cells found in small intestine

• intraepithelial lymphocyte to epithelial cell ratio is decreased 2-fold in small intestine

decreased double-positive T cell number ( J:72386 )

• 3-fold fewer lymphoid cells from E14.5-E17.5, corrected by E18.5

• 15-20 fold fewer double positive cells at E16.5

increased T cell number ( J:72386 )

• 2-3 fold increase in peripheral T cell receptor gamma/delta cells found in lymph nodes and spleen

Genotype
MGI:3799634

cx3

• Allelic Composition: Ccr9^tm1.1Mal/Ccr9^tm1.1Mal; Tnf^tm2Gkl/Tnf⁺
• Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

immune system

intestinal inflammation ( J:136667 )

• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles

• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles

abnormal T cell subpopulation ratio ( J:136667 )

• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnf^tm2Gkl alone

decreased gamma-delta intraepithelial T cell number ( J:136667 )

• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnf^tm2Gkl alone

abnormal alpha-beta intraepithelial T cell morphology ( J:136667 )

• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnf^tm2Gkl alone

digestive/alimentary system

intestinal inflammation ( J:136667 )

• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles

• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles

hematopoietic system

abnormal T cell subpopulation ratio ( J:136667 )

• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnf^tm2Gkl alone

decreased gamma-delta intraepithelial T cell number ( J:136667 )

• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnf^tm2Gkl alone

abnormal alpha-beta intraepithelial T cell morphology ( J:136667 )

• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnf^tm2Gkl alone