Analysis Tools
nervous system
| N |
• Background Sensitivity: the enlarged brain mass observed in Cd81tm1Lvy homozygotes on BALB/c and mixed backgrounds is not observed on this background
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Allele Symbol Allele Name Allele ID |
Cd81tm1Lvy targeted mutation 1, Shoshana Levy MGI:2180805 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Background Sensitivity: the enlarged brain mass observed in Cd81tm1Lvy homozygotes on BALB/c and mixed backgrounds is not observed on this background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• peribronchial lymph node lymphocytes from OVA challenged mice produce much less IFN-gamma, IL-4, IL-5 and IL-13 upon restimulation
• splenocytes from OVA-challenged mice produce half the IFN-gamma, IL-4 and IL-13 as controls
• T cells can be differentiated into Th2 effector cells in vitro
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• sensitized mice have decreased airway hyperresponsiveness to ova antigen after previously exposure
• mice have much reduced peribronchiolar and perivascular inflammatory infiltrates after OVA challenge with no sign of hypertrophy or mucin
• B cells numbers in peribronchiolar lymph nodes of OVA challenged mice are reduced by about half
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• Background Sensitivity: there is a modest increase in brain weight compared to littermate controls on while no effect is seen by the null mutation on a C57BL/6 background
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• Background Sensitivity: hippocampus volume is slightly larger unlike on C57BL/6 background where no significant effect is seen
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• Background Sensitivity: the cerebral cortex is thicker than controls on a mixed background which contributes to the increased brain weight of this strain of mice
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• peribronchial lymph node lymphocytes from OVA challenged mice produce much less IFN-gamma, IL-4, IL-5 and IL-13 upon restimulation
• splenocytes from OVA-challenged mice produce half the IFN-gamma, IL-4 and IL-13 as controls
• T cells can be differentiated into Th2 effector cells in vitro
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: brains are about 20% heavier than littermate controls on this F1 background while no effect is seen by the null mutation on a C57BL/6 background
• Background Sensitivity: the mean brain weight is 570 mg, which is three standard deviations higher than that of typical mice
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• despite increased brain size, corpus callosum cross sectional area is comparable to controls
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• mice have a 7.5% increase in the thickness of CA1 relative to the normal littermates
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• Background Sensitivity: hippocampus volume is significantly larger unlike on C57BL/6 background where no significant effect is seen
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• Background Sensitivity: the cerebral cortex is thicker than controls on a F1 background which contributes to the increased brain weight of this strain of mice
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• the glial cell to neuronal cell ratio is significantly increased in the neocortex
• neuronal cell density is decreased while glial cell density is normal indicating increased number of glial cells
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• numbers of microglial cells in the hippocampus are increased by 58%
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• astrocyte cell size is not enlarged
• there is a significant increase in the number of astrocytes within the hippocampus relative to their control littermates
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• neuronal cell density is decreased due to increased glial cell number
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• there is a greater expanse of the pyramidal cells' dendritic fields
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• numbers of microglial cells in the hippocampus are increased by 58%
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• numbers of microglial cells in the hippocampus are increased by 58%
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• B cells have reduced expression of CD19
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• total IgG levels are reduced 4 and 8 weeks after mice are immunized with ovalbumin
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• IgG1 levels are reduced 4 and 8 weeks after mice are immunized with ovalbumin
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• mice have less Th2-mediated immunoglobin response to ovalbumin, a Th2 antigen
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• mice are resistant to Plasmodium yoelii and P.falciparum infection when administered sporozoites IV
• mice are not resistant to infection with intraperitoneal inoculation of P. yoelii-infected erythrocytes
• the exoerythrocytic form of the parasite is not detected in the liver after sporozoite infection as occurs in controls
• parasites fail to form intracellular vacuoles in hepatocytes as occurs in infected wild-type hepatocytes
• mice are not resistant to P. Berghei infection which use a CD81-independent mechanism to form vacuoles in hepatocytes
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• B cells have reduced expression of CD19
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• total IgG levels are reduced 4 and 8 weeks after mice are immunized with ovalbumin
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• IgG1 levels are reduced 4 and 8 weeks after mice are immunized with ovalbumin
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• mice have less Th2-mediated immunoglobin response to ovalbumin, a Th2 antigen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: brains are about 20% heavier than littermate controls on a mixed background while no effect is seen by the null mutation on a C57BL/6 background
• Background Sensitivity: the mean brain weight is 570 mg-three standard deviations higher than that of typical mice
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• hippocampus are enlarged with increased numbers of astrocytes
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• mice have a 7.5% increase in the thickness of CA1 relative to the normal littermates
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• Background Sensitivity: hippocampus volume is significantly larger unlike on C57BL/6 background where no significant effect is seen
|
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• Background Sensitivity: the cerebral cortex is thicker than controls on a mixed background which contributes to the increased brain weight of this strain of mice
|
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• the glial cell to neuronal cell ratio is significantly increased in the neocortex
• neuronal cell density is decreased while glial cell density is normal indicating increased number of glial cells
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• there is a significant increase in the number of astrocytes within the hippocampus relative to their control littermates
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• neuronal cell density is decreased due to increased glial cell number
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• there is a greater expanse of the pyramidal cells' dendritic fields
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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