Cd81^tm1Lvy
Targeted Allele Detail

Summary

• Symbol: Cd81^tm1Lvy
• Name: CD81 antigen; targeted mutation 1, Shoshana Levy
• MGI ID: MGI:2180805
• Synonyms: CD81^-
• Gene: Cd81 Location: Chr7:142606487-142621667 bp, + strand Genetic Position: Chr7, 88.1 cM
• Alliance: Cd81^tm1Lvy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40394
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 2 through 8. Flow cytometric analysis of protein surface expression detected only background levels of staining in thymocytes isolated from homozygous mutant mice. (J:40394)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd81 Mutation: 21 strains or lines available

References

• Original: J:40394 Maecker HT, et al., Normal lymphocyte development but delayed humoral immune response in CD81-null mice. J Exp Med. 1997 Apr 21;185(8):1505-10
• All: 14 reference(s)