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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd3gtm1Amk
targeted mutation 1, Ada M Kruisbeek
MGI:2180763
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd3gtm1Amk/Cd3gtm1Amk involves: 129P2/OlaHsd MGI:2673303
cx2
 		Cd3gtm1Amk/Cd3gtm1Amk
Tg(Igh-Pim1)1Brn/0 		involves: 129P2/OlaHsd * C57BL/6LiA * CBA MGI:3698156


Genotype
MGI:2673303
hm1
Allelic
Composition		 Cd3gtm1Amk/Cd3gtm1Amk
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3gtm1Amk mutation (0 available); any Cd3g mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:77504 )
• reduced thymic cellularity
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
abnormal T cell differentiation ( J:77504 )
• defective alpha-beta and gamma-delta T cell development
abnormal T cell physiology ( J:77504 )
• attenuated T cell response, putatively due to a decrease in the surface expression of mature TCR complexes
abnormal CD8-positive, alpha-beta T cell physiology ( J:77504 )
• expansion of an antigen-specific CD8 T cell population is completely abrogated after infection with influenza A virus
decreased cytotoxic T cell cytolysis ( J:77504 )
• polyclonal induction of cytotoxic T-cell activity under suboptimal conditions results in a reduction in the proliferative response of T cells and completely abolishes cytolytic activity of the effector T cells
abnormal T cell activation ( J:77504 )
• reduced T cell activation in response to anti-CD3epsilon mAb
abnormal T cell proliferation ( J:77504 )
• peripheral T cells show delayed proliferation and cytokine secretion in response to anti-CD3epsilon-mediated triggering, presumably due to impaired TCR complex expression
lymph node hypoplasia ( J:77504 )
• reduced lymph node cellularity

hematopoietic system
thymus hypoplasia ( J:77504 )
• reduced thymic cellularity
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
abnormal T cell differentiation ( J:77504 )
• defective alpha-beta and gamma-delta T cell development
abnormal T cell physiology ( J:77504 )
• attenuated T cell response, putatively due to a decrease in the surface expression of mature TCR complexes
abnormal CD8-positive, alpha-beta T cell physiology ( J:77504 )
• expansion of an antigen-specific CD8 T cell population is completely abrogated after infection with influenza A virus
decreased cytotoxic T cell cytolysis ( J:77504 )
• polyclonal induction of cytotoxic T-cell activity under suboptimal conditions results in a reduction in the proliferative response of T cells and completely abolishes cytolytic activity of the effector T cells
abnormal T cell activation ( J:77504 )
• reduced T cell activation in response to anti-CD3epsilon mAb
abnormal T cell proliferation ( J:77504 )
• peripheral T cells show delayed proliferation and cytokine secretion in response to anti-CD3epsilon-mediated triggering, presumably due to impaired TCR complex expression

endocrine/exocrine glands
thymus hypoplasia ( J:77504 )
• reduced thymic cellularity
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice

cellular
abnormal T cell proliferation ( J:77504 )
• peripheral T cells show delayed proliferation and cytokine secretion in response to anti-CD3epsilon-mediated triggering, presumably due to impaired TCR complex expression




Genotype
MGI:3698156
cx2
Allelic
Composition		 Cd3gtm1Amk/Cd3gtm1Amk
Tg(Igh-Pim1)1Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3gtm1Amk mutation (0 available); any Cd3g mutation (24 available)
Tg(Igh-Pim1)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice

hematopoietic system
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• thymocyte number is only about 1-2 x 106 cells at 4-5 weeks of age compared to 200-300 x 106 cells in wild-type mice
• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory