All Phenotypes Cxcr3<tm1Wwh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcr3^tm1Wwh/Cxcr3^tm1Wwh	B6.Cg-Cxcr3^tm1Wwh	MGI:3694964
hm2	Cxcr3^tm1Wwh/Cxcr3^tm1Wwh	Not Specified	MGI:4830341
cx3	Cxcr3^tm1Wwh/Y Tg(TRAMP)8247Ng/?	involves: C57BL/6	MGI:3694967
ot4	Cxcr3^tm1Wwh/Y	B6.Cg-Cxcr3^tm1Wwh	MGI:3694965

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:96905 )

• most survive infection with lymphocytic choriomeningitis virus which is cleared in 1 month in survivors, controls do not survive

immune system

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:96905 , J:107646 )

• reduced numbers of CD8+ cells in the brain 7 days after infection with lymphocytic choriomeningitis (J:96905)

• restricted to meninges and choroids plexus until late in infection unlike controls where white matter of the brain near ventricular surfaces will be penetrated by CD8+ cells (J:96905)

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia (J:107646)

abnormal interferon level ( J:91359 )

• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days

lung inflammation ( J:91359 )

• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury

• reduced numbers of CD8+ T cells after bleomycin injury

• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice

decreased susceptibility to Riboviria infection ( J:96905 )

• lack symptoms of infection at 7 days after infection with lymphocytic choriomeningitis virus

• less susceptibility to lymphocytic choriomeningitis virus

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:96905 )

• most survive infection with lymphocytic choriomeningitis virus which is cleared in 1 month in survivors, controls do not survive

increased length of allograft survival ( J:65916 )

• increased cardiac allograft survival

• grafts with fewer Cd4+ and Cd8+ T cells

respiratory system

lung inflammation ( J:91359 )

• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury

• reduced numbers of CD8+ T cells after bleomycin injury

• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice

pulmonary interstitial fibrosis ( J:91359 )

• more severe and extensive interstitial fibrosis in response to bleomycin injury

• increased collagen deposition by day 21

• 50% mortality

• treatment with exogenous IFN-gamma partially alleviates tissue fibrosis

cardiovascular system

abnormal physiological neovascularization ( J:107646 )

• ischemic capillary density relative to nonischemic density 1.4 fold lower than in controls

• poor recovery of blood flow after ischemia

homeostasis/metabolism

abnormal interferon level ( J:91359 )

• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days

cellular

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:96905 , J:107646 )

• reduced numbers of CD8+ cells in the brain 7 days after infection with lymphocytic choriomeningitis (J:96905)

• restricted to meninges and choroids plexus until late in infection unlike controls where white matter of the brain near ventricular surfaces will be penetrated by CD8+ cells (J:96905)

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia (J:107646)

hematopoietic system

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:96905 , J:107646 )

• reduced numbers of CD8+ cells in the brain 7 days after infection with lymphocytic choriomeningitis (J:96905)

• restricted to meninges and choroids plexus until late in infection unlike controls where white matter of the brain near ventricular surfaces will be penetrated by CD8+ cells (J:96905)

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia (J:107646)

Allelic Composition	Cxcr3^tm1Wwh/Cxcr3^tm1Wwh
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr3^tm1Wwh mutation (1 available); any Cxcr3 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:163822 )

• B16 melenoma tumor growth is significantly faster compared with wild-type mice

Allelic Composition	Cxcr3^tm1Wwh/Y Tg(TRAMP)8247Ng/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr3^tm1Wwh mutation (1 available); any Cxcr3 mutation (10 available)
Tg(TRAMP)8247Ng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor growth/size ( J:115957 )

• prostate tumors detectable earlier than in controls, by 10-15 weeks of age

• greater tumor mass than controls until about 20 weeks of age but not thereafter

Allelic Composition	Cxcr3^tm1Wwh/Y
Genetic Background	B6.Cg-Cxcr3^tm1Wwh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr3^tm1Wwh mutation (1 available); any Cxcr3 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:107646 )

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia

abnormal interferon level ( J:91359 )

• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days

lung inflammation ( J:91359 )

• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury

• reduced numbers of CD8+ T cells after bleomycin injury

• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice

increased length of allograft survival ( J:65916 )

• increased cardiac allograft survival

• grafts with fewer Cd4+ and Cd8+ T cells

respiratory system

lung inflammation ( J:91359 )

• decreased total lymphocyte counts in bronchoalveolar lavage after bleomycin injury

• reduced numbers of CD8+ T cells after bleomycin injury

• reduced numbers of NK cells at day 7 after bleomycin injury, but also in the lungs of unchallenged mice

pulmonary interstitial fibrosis ( J:91359 )

• more severe and extensive interstitial fibrosis in response to bleomycin injury

• increased collagen deposition by day 21

• 50% mortality

• treatment with exogenous IFN-gamma partially alleviates tissue fibrosis

cardiovascular system

abnormal physiological neovascularization ( J:107646 )

• ischemic capillary density relative to nonischemic density 1.4 fold lower than in controls

• poor recovery of blood flow after ischemia

homeostasis/metabolism

abnormal interferon level ( J:91359 )

• increased levels of IFN-gamma in lung tissue and in bronchoalveolar lavage 1 day after treatment with bleomycin, effect dissipates after 3 days

cellular

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:107646 )

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia

hematopoietic system

impaired macrophage chemotaxis ( J:107646 )

• 45% decrease of monocyte/macrophage in ischemic calf and thigh muscle

abnormal cellular extravasation ( J:107646 )

• 38% decrease in numbers of CD3+ T cells in ischemic calf and thigh muscles at 7 days but not at 21 days after ischemia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23