Analysis Tools
vision/eye
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• at E18, retinas are thinner than in wild-type mice
• however, retinal ganglion cell axons are routed normally
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Allele Symbol Allele Name Allele ID |
Ccnd1tm1Dsn targeted mutation 1, Clive Dickson MGI:2180640 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E18, retinas are thinner than in wild-type mice
• however, retinal ganglion cell axons are routed normally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a significant fraction of mutants died early in life, often within the first 3 weeks
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• a significant fraction of mutants displayed embryonic lethality
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• all homozygotes showed a "leg-clasping" reflex: when lifted by their tails, they drew their limbs toward the trunk
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• both male and female mutants were fertile; however, litters were invariably killed by their mothers and never survived beyond the second day
• such litters could only be rescued when cross-fostered
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| N |
• MEF cultures obtained from E14 mutant embryos showed normal growth rates and cell-cycle kinetics
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• about 50% of homozygotes displayed incisor misalignment, leading to their excssive growth
• in a few severe cases, incisors need to be cut to allow mice to feed properly
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• about 50% of homozygotes displayed incisor misalignment
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• misalignment of incisors was caused by lateral distortion of the mandibles in the anterior part of the jaw
• incisor misalignment did not affect feeding or overall size, as mice without such defects were equally runted
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• in one case, there was a marked distortion of the maxilla on one side
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• at mid-pregnant and postpartum stages, mammary glands failed to undergo normal lobuloalveolar development
• at these stages, mammary glands showed poor acinar development and little secretory activity
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• at mid-pregnant and postpartum stages, mammary glands failed to undergo normal lobuloalveolar development
• at these stages, mammary glands showed poor acinar development and little secretory activity
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• females were unable to nurse newborn pups due to the failure of mammary tissue development
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• about 50% of homozygotes displayed incisor misalignment, leading to their excssive growth
• in a few severe cases, incisors need to be cut to allow mice to feed properly
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• about 50% of homozygotes displayed incisor misalignment
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• all homozygotes were 10%-40% smaller than wild-type during growth to adulthood
• the weights and sizes of major organs were proportionately lower, consistent with reduced size
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• at mid-pregnant and postpartum stages, mammary glands failed to undergo normal lobuloalveolar development
• at these stages, mammary glands showed poor acinar development and little secretory activity
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• about 50% of homozygotes displayed incisor misalignment, leading to their excssive growth
• in a few severe cases, incisors need to be cut to allow mice to feed properly
|
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• about 50% of homozygotes displayed incisor misalignment
|
|
• misalignment of incisors was caused by lateral distortion of the mandibles in the anterior part of the jaw
• incisor misalignment did not affect feeding or overall size, as mice without such defects were equally runted
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• in one case, there was a marked distortion of the maxilla on one side
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• mutant eyes showed a reduction in the organization of the surface ganglion cell layer; the remainder of the eye structure appeared normal
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• mutant eyes showed a reduction in the thickness of the surface ganglion cell layer
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• homozygotes showed a striking reduction in thickness and organization of all retinal layers, esp. the outer layer, as well as disorganization of nuclear polarity
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• homozygotes had hypoplastic, grossly underdeveloped retinas
• abnormal retinal features were consistent with a severe bilateral retinopathy
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• at mid-pregnant and postpartum stages, mammary glands failed to undergo normal lobuloalveolar development
• at these stages, mammary glands showed poor acinar development and little secretory activity
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• at mid-pregnant and postpartum stages, mammary glands failed to undergo normal lobuloalveolar development
• at these stages, mammary glands showed poor acinar development and little secretory activity
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• females were unable to nurse newborn pups due to the failure of mammary tissue development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double homozygotes showed increased susceptibility to pituitary adenomas arising from the intermediate lobe
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| N |
• double homozygotes did not display premature mortality and developed normally
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• double homozygotes showed increased susceptibility to pituitary adenomas arising from the intermediate lobe
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• double homozygotes showed only a moderate "leg-clasping" reflex
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| N |
• double mutant mice never displayed misaligned teeth
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| N |
• double homozygotes showed normal lobuloalveolar development of the mammary epithelium
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• double homozygotes displayed an ovarian defect associated with the inability of cells forming corpus luteum to undergo a timely cell cycle exit
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• double homozygotes showed increased susceptibility to pituitary adenomas arising from the intermediate lobe
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• double homozygotes showed an increased body mass, albeit lower than that observed in single Cdkn1b mutant mice
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• double homozygotes displayed an ovarian defect associated with the inability of cells forming corpus luteum to undergo a timely cell cycle exit
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• despite normal retinal development, double homozygotes displayed focal disorganization of the retinal cytoarchitecture
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by E15.5 embryos appear pale
• by E16.5 no viable embryos are observed
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• embryonic
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• thinned walls of embryonic heart ventricles, mainly in compact zone
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• total number of fetal liver cells reduced at E14.5
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• common myeloid progenitors cells substantially reduced
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• common lymphoid progenitors cells reduced by 46 fold
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• E14.5 embryos exhibit 8-fold decrease in peripheral blood erythrocytes
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• impaired ability of hematopoietic stem cells to proliferate
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• hematopoietic stem cells reduced 5.7 fold in E14.5 liver
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• embryonic
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• common lymphoid progenitors cells reduced by 46 fold
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice heterozygous for "multiple intestinal neoplasia" (F2 Min) and homozygous null for Ccnd1tm1Dsn developed significantly fewer tumors (tumor range: 1-39) than mice doubly heterozygous for Min and Ccnd1tm1Dsn (tumor range: 3-129) or mice heterozygous for Min and wild-type for Ccnd1 (tumor range: 2-112)
• no difference in tumor size was observed between the various Ccnd1 genotypes in heterozygous F2 Min mice
• also, no association was found between tumor number and animal weight
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• mice heterozygous for "multiple intestinal neoplasia" (F2 Min) and homozygous null for Ccnd1tm1Dsn developed significantly fewer tumors (tumor range: 1-39) than mice doubly heterozygous for Min and Ccnd1tm1Dsn (tumor range: 3-129) or mice heterozygous for Min and wild-type for Ccnd1 (tumor range: 2-112)
• no difference in tumor size was observed between the various Ccnd1 genotypes in heterozygous F2 Min mice
• also, no association was found between tumor number and animal weight
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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