All Phenotypes Otp<tm1Asim> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Otp^tm1Asim
targeted mutation 1, Antonio Simeone
MGI:2180541

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otp^tm1Asim/Otp^tm1Asim	involves: 129P2/OlaHsd	MGI:3713801
ht2	Otp^tm1Asim/Otp⁺	C3H.129P2(B6)-Otp^tm1Asim	MGI:6402819
ht3	Otp^M1H/Otp^tm1Asim	involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J	MGI:6402821

Allelic Composition	Otp^tm1Asim/Otp^tm1Asim
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otp^tm1Asim mutation (1 available); any Otp mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dopaminergic neuron morphology ( J:122105 )

• dopanergic neurons in group A11 are mis-specified or lose their specificity as shown by the loss of tyrosine hydroxylase, Nkx2.1, Otx and AADC staining at E11.5 and E15.5

Allelic Composition	Otp^tm1Asim/Otp⁺
Genetic Background	C3H.129P2(B6)-Otp^tm1Asim

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otp^tm1Asim mutation (1 available); any Otp mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased body fat mass ( J:251771 , J:251771 )

	• from age 8 weeks on regular chow (J:251771)
	• between age 6 and 12 and at 18 weeks on regular chow (J:251771)

growth/size/body

increased body fat mass ( J:251771 , J:251771 )

	• from age 8 weeks on regular chow (J:251771)
	• between age 6 and 12 and at 18 weeks on regular chow (J:251771)

increased lean body mass ( J:251771 , J:251771 )

	• from age 10 weeks on regular chow (J:251771)
	• from age 6 weeks on regular chow (J:251771)

obese ( J:251771 )

homeostasis/metabolism

increased circulating leptin level ( J:251771 )

• at age 8 and 12 weeks on regular chow after 5-6h fast

impaired glucose tolerance ( J:251771 )

• at age 12 weeks on regular chow after 5-6h fast

insulin resistance ( J:251771 , J:251771 )

	• no insulin resistance at age 12 weeks on regular chow after 5-6h fast (J:251771)
	• at age 12 weeks on regular chow after 5-6h fast (J:251771)

Allelic Composition	Otp^M1H/Otp^tm1Asim
Genetic Background	involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otp^M1H mutation (2 available); any Otp mutation (19 available)
Otp^tm1Asim mutation (1 available); any Otp mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:251771 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24