All Phenotypes Itga3<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itga3⁺
wild type
MGI:2180463

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd151^tm2Nki/Cd151^tm2Nki Itga3^tm1Son/Itga3⁺ Krt14^tm1(cre)Wbm/?	FVB.129P2-Cd151^tm2Nki Itga3^tm1Son Krt14^tm1(cre)Wbm	MGI:5550138
cx2	Itga3^tm1Jak/Itga3⁺ Itga5^tm1Hyn/Itga5⁺ Itga8^tm1Lfr/Itga8⁺	involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6J	MGI:3583667
cx3	Itga3^tm1Jak/Itga3⁺ Itga8^tm1Lfr/Itga8⁺	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J	MGI:3583665

Allelic Composition	Cd151^tm2Nki/Cd151^tm2Nki Itga3^tm1Son/Itga3⁺ Krt14^tm1(cre)Wbm/?
Genetic Background	FVB.129P2-Cd151^tm2Nki Itga3^tm1Son Krt14^tm1(cre)Wbm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd151^tm2Nki mutation (0 available); any Cd151 mutation (36 available)
Itga3^tm1Son mutation (0 available); any Itga3 mutation (52 available)
Krt14^tm1(cre)Wbm mutation (0 available); any Krt14 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

• however, overall benign and malignant histology is normal

decreased tumor growth/size ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

integument

decreased keratinocyte proliferation ( J:205736 )

• in papillomas of DMBA- and TPA-treated mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:205736 )

• reduced tumor volume and incidents in DMBA- and TPA-treated mice more so than in Cd151^tm2Nki/Cd151^tm2Nki Krt14^tm1(cre)Wbm mice

• however, overall benign and malignant histology is normal

cellular

decreased keratinocyte proliferation ( J:205736 )

• in papillomas of DMBA- and TPA-treated mice

Allelic Composition	Itga3^tm1Jak/Itga3⁺ Itga5^tm1Hyn/Itga5⁺ Itga8^tm1Lfr/Itga8⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3^tm1Jak mutation (0 available); any Itga3 mutation (52 available)
Itga5^tm1Hyn mutation (1 available); any Itga5 mutation (46 available)
Itga8^tm1Lfr mutation (2 available); any Itga8 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

reduced long-term potentiation ( J:84858 )

• nearly complete elimination of long term potentiation after 60 minutes

behavior/neurological

abnormal spatial learning ( J:84858 )

• deficient in spatial memory in a Morris water maze test

• normal fear conditioning however

Allelic Composition	Itga3^tm1Jak/Itga3⁺ Itga8^tm1Lfr/Itga8⁺
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3^tm1Jak mutation (0 available); any Itga3 mutation (52 available)
Itga8^tm1Lfr mutation (2 available); any Itga8 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

reduced long-term potentiation ( J:84858 )

• increasingly severe deficient long term potentiation response shortly after tetanus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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