Phenotypes associated with this allele

• Allele Symbol: Irf1⁺
• Allele Name: wild type
• Allele ID: MGI:2180205
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Irf1^M1Btlr/Irf1^+	C57BL/6J-Irf1^M1Btlr	MGI:4821110
ht2	Irf1^tm1Mak/Irf1^+	either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J * DBA/2)	MGI:3769111
cx3	Fas^lpr/Fas^lpr Irf1^tm1Mak/Irf1^+	MRL.Cg-Irf1^tm1Mak Fas^lpr	MGI:3769144

Genotype
MGI:4821110

ht1

• Allelic Composition: Irf1^M1Btlr/Irf1⁺
• Genetic Background: C57BL/6J-Irf1^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:162995 )

N • the blood of both homozygous and heterozygous mutant mice contains normal numbers of CD4⁺ T cells, CD19⁺ B cells and CD11c⁺ dendritic cells

decreased NK cell number ( J:162995 )

• the bloood of heterozygous mutant mice contains a reduced number of NK1.1⁺ cells, intermediate between those of wild-type and of homozygous mutant mice

decreased CD8-positive, alpha-beta T cell number ( J:162995 )

• the bloood of heterozygous mutant mice contains a reduced number of CD8⁺ cells, intermediate between those of wild-type and of homozygous mutant mice

impaired natural killer cell mediated cytotoxicity ( J:162995 )

• natural killer (NK) cells from previously immunized heterozygous mutant mice exhibit diminished ability to kill class I MHC-deficient cells in vivo; the level of killing is intermediate between that of wild-type and of homozygous mutant mice

immune system

immune system phenotype ( J:162995 )

N • the blood of both homozygous and heterozygous mutant mice contains normal numbers of CD4⁺ T cells, CD19⁺ B cells and CD11c⁺ dendritic cells

N • CD8⁺ cytotoxic T lymphocytes (CTL) from previously immunized homozygus and heterozygous mutant mice exhibit normal ability of to kill antigen-specific target cells in vivo

decreased NK cell number ( J:162995 )

• the bloood of heterozygous mutant mice contains a reduced number of NK1.1⁺ cells, intermediate between those of wild-type and of homozygous mutant mice

decreased CD8-positive, alpha-beta T cell number ( J:162995 )

• the bloood of heterozygous mutant mice contains a reduced number of CD8⁺ cells, intermediate between those of wild-type and of homozygous mutant mice

impaired natural killer cell mediated cytotoxicity ( J:162995 )

• natural killer (NK) cells from previously immunized heterozygous mutant mice exhibit diminished ability to kill class I MHC-deficient cells in vivo; the level of killing is intermediate between that of wild-type and of homozygous mutant mice

increased susceptibility to Herpesvirales infection ( J:162995 )

• heterozygous mutants exhibit enhanced susceptibility to infection with 2 x 10⁵ PFU of mouse cytomegalovirus (MCMV)

Genotype
MGI:3769111

ht2

• Allelic Composition: Irf1^tm1Mak/Irf1⁺
• Genetic Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J * DBA/2)

normal phenotype

no abnormal phenotype detected ( J:64286 )

• mice are viable and fertile, with no detectable abnormalities

Genotype
MGI:3769144

cx3

• Allelic Composition: Fas^lpr/Fas^lpr; Irf1^tm1Mak/Irf1⁺
• Genetic Background: MRL.Cg-Irf1^tm1Mak Fas^lpr

mortality/aging

premature death ( J:114771 )

• 50% of mice die by 52 weeks; survival is increased relative to MRL-Fas^lpr mice

renal/urinary system

increased urine protein level ( J:114771 )

• not significantly different from Fas^lpr, Irf1-null mice or Fas^lpr, Irf1-sufficient mice

glomerulonephritis ( J:114771 )

• at 26 weeks of age, mice show much less severe renal disease including IgG and C3 glomerular deposition compared to Fas^lpr homozygotes

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:114771 )

• mice display similar T cell population profiles to Fas^lpr, Irf1-null mice

immune system

immune system phenotype ( J:114771 )

N • TNF alpha production is not significantly different Fas^lpr, Irf1-sufficient mice or Fas^lpr, Irf1-null mice

increased CD4-positive, alpha-beta T cell number ( J:114771 )

• mice display similar T cell population profiles to Fas^lpr, Irf1-null mice

increased anti-double stranded DNA antibody level ( J:114771 )

• at 26 weeks of age, levels are significantly higher relative to Fas^lpr, Irf1-null mice

glomerulonephritis ( J:114771 )

• at 26 weeks of age, mice show much less severe renal disease including IgG and C3 glomerular deposition compared to Fas^lpr homozygotes

homeostasis/metabolism

increased urine protein level ( J:114771 )

• not significantly different from Fas^lpr, Irf1-null mice or Fas^lpr, Irf1-sufficient mice

integument

abnormal skin condition ( J:114771 )

• mice display varying severity of skin irritation ranging from little or none to mild or moderate to severe