About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il6+
wild type
MGI:2180047
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Il6tm1Mur/Il6+ B6.129P2(B6)-Il6tm1Mur MGI:3604661
cn2
 		Il6tm1Kopf/Il6+
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA MGI:5515639
cn3
 		Il6tm1.1Jho/Il6+
Tg(GFAP-cre)8Gtm/0 		involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:5577073
cx4
 		Il6tm1Kopf/Il6+
Tg(ED-L2-IL1RN/IL1B)#Tcw/? 		B6.Cg-Il6tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw MGI:5308015
cx5
 		Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+ 		involves: 129 * 129S2/SvPas * C57BL/6 MGI:7294376
cx6
 		Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+ 		involves: 129S2/SvPas * BALB/c * C57BL/6 MGI:5581716
cx7
 		Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+ 		involves: 129S2/SvPas * C57BL/6 MGI:5581715
cx8
 		Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5tm1Hxia 		involves: 129S2/SvPas * C57BL/6 MGI:5581717
cx9
 		Galctwi/Galctwi
Il6+/? 		involves: 129S2/SvPas * C57BL/6J * CE/J MGI:4452147


Genotype
MGI:3604661
ht1
Allelic
Composition		 Il6tm1Mur/Il6+
Genetic
Background		 B6.129P2(B6)-Il6tm1Mur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Mur mutation (0 available); any Il6 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal dopamine level ( J:86039 )
• after a single injection of MPTP (30 mg/kg), heterozygotes exhibit a significantly greater striatal dopamine depletion relative to wild-type mice, suggesting a gene dosage effect




Genotype
MGI:5515639
cn2
Allelic
Composition		 Il6tm1Kopf/Il6+
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (10 available); any Il6 mutation (39 available)
Prdm1tm1Clme mutation (1 available); any Prdm1 mutation (69 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:178876 )
N
• mice do not develop autoantibodies, they mount an antibody response indistinguishable from control mice to NP-CGG, dendritic cells express the same level of IL-6 as dendritic cells from control mice after LPS stimulation, and show normal levels of follicular T helper cells and germinal cells in the spleen




Genotype
MGI:5577073
cn3
Allelic
Composition		 Il6tm1.1Jho/Il6+
Tg(GFAP-cre)8Gtm/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1.1Jho mutation (1 available); any Il6 mutation (39 available)
Tg(GFAP-cre)8Gtm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased locomotor activity ( J:211914 )
• intermediate decreased ambulation in female mice subjected to the hole-board test




Genotype
MGI:5308015
cx4
Allelic
Composition		 Il6tm1Kopf/Il6+
Tg(ED-L2-IL1RN/IL1B)#Tcw/?
Genetic
Background		 B6.Cg-Il6tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (10 available); any Il6 mutation (39 available)
Tg(ED-L2-IL1RN/IL1B)#Tcw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:180282 )
N
• reduced of Il6 expression completely decreases metaplasia and abolishes dysplasia

immune system




Genotype
MGI:7294376
cx5
Allelic
Composition		 Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+
Genetic
Background		 involves: 129 * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (10 available); any Il6 mutation (39 available)
Ncoa5tm1Hxia mutation (0 available); any Ncoa5 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:284227 )
• SEM and TEM analyses of cauda epididymal sperm showed significantly improved sperm ultrastructure relative to single Ncoa5tm1Hxia male heterozygotes
increased sperm motility ( J:284227 )
• at 4 months of age, the % of motile cauda epididymal sperm is significantly higher than that in single Ncoa5tm1Hxia male heterozygotes
increased sperm progressive motility ( J:284227 )
• at 4 months of age, the % of progressively motile sperm is significantly higher than that in single Ncoa5tm1Hxia male heterozygotes
enhanced male fertility ( J:284227 )
• when bred with double heterozygous females, 5 out of 6 double heterozygous males are able to father litters with 2 to 8 pups per litter, in contrast to single Ncoa5tm1Hxia male heterozygotes
abnormal epididymis physiology ( J:284227 )
• at 4.5 months of age, IHC staining showed that epididymal expression of IL-6 is markedly lower than that in single Ncoa5tm1Hxia male heterozygotes

cellular
teratozoospermia ( J:284227 )
• SEM and TEM analyses of cauda epididymal sperm showed significantly improved sperm ultrastructure relative to single Ncoa5tm1Hxia male heterozygotes
increased sperm motility ( J:284227 )
• at 4 months of age, the % of motile cauda epididymal sperm is significantly higher than that in single Ncoa5tm1Hxia male heterozygotes
increased sperm progressive motility ( J:284227 )
• at 4 months of age, the % of progressively motile sperm is significantly higher than that in single Ncoa5tm1Hxia male heterozygotes




Genotype
MGI:5581716
cx6
Allelic
Composition		 Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (10 available); any Il6 mutation (39 available)
Ncoa5tm1Hxia mutation (0 available); any Ncoa5 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:207622 )
N
• unlike Ncoa5tm1Hxia male heterozygotes, male mice exhibit normal circulating glucose levels and improved glucose tolerance




Genotype
MGI:5581715
cx7
Allelic
Composition		 Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (10 available); any Il6 mutation (39 available)
Ncoa5tm1Hxia mutation (0 available); any Ncoa5 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocellular carcinoma incidence ( J:207622 )
• fewer and smaller maximum tumor volume than in Ncoa5tm1Hxia male heterozygotes

reproductive system
reproductive system phenotype ( J:207622 )
N
• unlike Ncoa5tm1Hxia male heterozygotes, male mice are fertile

neoplasm
increased hepatocellular carcinoma incidence ( J:207622 )
• fewer and smaller maximum tumor volume than in Ncoa5tm1Hxia male heterozygotes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:207622 )
N
• unlike Ncoa5tm1Hxia male heterozygotes, male mice exhibit normal circulating glucose levels, glucose tolerance and insulin sensitivity




Genotype
MGI:5581717
cx8
Allelic
Composition		 Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5tm1Hxia
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (10 available); any Il6 mutation (39 available)
Ncoa5tm1Hxia mutation (0 available); any Ncoa5 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:207622 )
• no mice are produced from fertile double heterozygotes




Genotype
MGI:4452147
cx9
Allelic
Composition		 Galctwi/Galctwi
Il6+/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * CE/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galctwi mutation (1 available); any Galc mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:56656 )
• Background Sensitivity: average lifespan is 39.29 days

cardiovascular system
abnormal blood-brain barrier function ( J:56656 )
• modest disruption of the blood-brain barrier detected by immunohistochemical detection of IgG or albumin
• lipopolysaccharide injection results in increased blood-brain barrier disruption and further shortens lifespan

homeostasis/metabolism
abnormal tumor necrosis factor level ( J:56656 )
• hindbrain has elevated TNF levels (9.38 pg/mg versus 6.54 pg/mg)

immune system
abnormal tumor necrosis factor level ( J:56656 )
• hindbrain has elevated TNF levels (9.38 pg/mg versus 6.54 pg/mg)

nervous system
abnormal blood-brain barrier function ( J:56656 )
• modest disruption of the blood-brain barrier detected by immunohistochemical detection of IgG or albumin
• lipopolysaccharide injection results in increased blood-brain barrier disruption and further shortens lifespan
gliosis ( J:56656 )
• severe gliosis in both gray and white matter regions
abnormal cerebellum white matter morphology ( J:56656 )
• the deep cerebellar white matter has periodic acid-Schiff staining globoid cells and lectin-positive macrophages
demyelination ( J:56656 )
• most severe in the hindbrain/cervical spinal cord

behavior/neurological
tremors ( J:56656 )
• the average onset of twitching is 25.85 days

cellular
gliosis ( J:56656 )
• severe gliosis in both gray and white matter regions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory