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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grap2tm1Amch
targeted mutation 1, Alec M Cheng
MGI:2180009
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grap2tm1Amch/Grap2tm1Amch involves: 129S1/Sv * 129X1/SvJ MGI:3576661
cx2
 		Grap2tm1Amch/Grap2tm1Amch
Lcp2tm1.1Wz/Lcp2tm1.1Wz 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3850712


Genotype
MGI:3576661
hm1
Allelic
Composition		 Grap2tm1Amch/Grap2tm1Amch
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grap2tm1Amch mutation (0 available); any Grap2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:76696 )
• 4 fold reduction in thymocytes
• fewer mature cells expressing high levels of TCR
increased double-negative T cell number ( J:76696 )
• modest increase in CD4-CD8- thymocytes
arrested T cell differentiation ( J:76696 )
• T cell development arrested at the CD44-CD25+ stage
decreased CD4-positive, alpha-beta T cell number ( J:76696 )
• 10 fold reduction in peripheral CD4+ T cells
• CD4+ cell numbers increased with time
decreased CD8-positive, alpha-beta T cell number ( J:76696 )
• 2 fold reduction in peripheral CD8+ T cells

hematopoietic system
decreased thymocyte number ( J:76696 )
• 4 fold reduction in thymocytes
• fewer mature cells expressing high levels of TCR
increased double-negative T cell number ( J:76696 )
• modest increase in CD4-CD8- thymocytes
arrested T cell differentiation ( J:76696 )
• T cell development arrested at the CD44-CD25+ stage
decreased CD4-positive, alpha-beta T cell number ( J:76696 )
• 10 fold reduction in peripheral CD4+ T cells
• CD4+ cell numbers increased with time
decreased CD8-positive, alpha-beta T cell number ( J:76696 )
• 2 fold reduction in peripheral CD8+ T cells

endocrine/exocrine glands
decreased thymocyte number ( J:76696 )
• 4 fold reduction in thymocytes
• fewer mature cells expressing high levels of TCR




Genotype
MGI:3850712
cx2
Allelic
Composition		 Grap2tm1Amch/Grap2tm1Amch
Lcp2tm1.1Wz/Lcp2tm1.1Wz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grap2tm1Amch mutation (0 available); any Grap2 mutation (23 available)
Lcp2tm1.1Wz mutation (0 available); any Lcp2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:150304 )
• T cell developmental defects are more severe than in either single homozygote
decreased double-positive T cell number ( J:150304 )
• CD4+CD8+ thymocytes make up only 18% of the total thymocytes
decreased single-positive T cell number ( J:150304 )
• very few mature T cells are detected in the periphery

hematopoietic system
abnormal T cell differentiation ( J:150304 )
• T cell developmental defects are more severe than in either single homozygote
decreased double-positive T cell number ( J:150304 )
• CD4+CD8+ thymocytes make up only 18% of the total thymocytes
decreased single-positive T cell number ( J:150304 )
• very few mature T cells are detected in the periphery




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory