All Phenotypes Il4<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Il4^tm1.1Wep/Il4⁺	C.129P2-Il4^tm1.1Wep	MGI:3818433
ht2	Il4^tm1(CD2)Irvr/Il4⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3713049
cn3	Il13^{tm1(YFP/cre)Lky}/Il13⁺ Il4^tm1(CD2)Mmrs/Il4⁺ Gt(ROSA)26Sor^tm1(DTA)Lky/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5435903
cx4	Il4^tm1.1Wep/Il4⁺ Stat6^tm1Gru/Stat6^tm1Gru	C.129-Stat6^tm1Gru Il4^tm1.1Wep	MGI:3818430
cx5	Cigs2^tm1.1Anse/Cigs2⁺ Il4^tm1(CD2)Mmrs/Il4⁺	involves: 129 * BALB/cJ * C57BL/6	MGI:5313999
cx6	Il13^tm1Anjm/Il13⁺ Il4^tm1.1Wep/Il4⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3818436
cx7	Il4^tm1Lky/Il4⁺ Lat^tm1.1Mal/Lat^tm1.1Mal	involves: 129S2/SvPas * C57BL/6	MGI:4357974

Allelic Composition	Il4^tm1.1Wep/Il4⁺
Genetic Background	C.129P2-Il4^tm1.1Wep

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1.1Wep mutation (0 available); any Il4 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgE level ( J:138827 )

• serum IgE is half that of controls 15 days after parasitic nematode infection

• serum IgE is also significantly reduced when the allergic airway model or the IgD neutralization model is induced

hematopoietic system

decreased IgE level ( J:138827 )

• serum IgE is half that of controls 15 days after parasitic nematode infection

• serum IgE is also significantly reduced when the allergic airway model or the IgD neutralization model is induced

Allelic Composition	Il4^tm1(CD2)Irvr/Il4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1(CD2)Irvr mutation (0 available); any Il4 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:111440 )

N	• allele activation is initially stochastic; frequency of biallelic expression Il-4 is independent of Il-4 levels but depends on T cell receptor signaling strength

immune system

immune system phenotype ( J:111440 )

N	• human CD2 reporter gene is expressed in Th2 and Th0 cells, but not in Th1 cells expressing only IFNgamma; expression is inducible upon T cell activation

Allelic Composition	Il13^{tm1(YFP/cre)Lky}/Il13⁺ Il4^tm1(CD2)Mmrs/Il4⁺ Gt(ROSA)26Sor^tm1(DTA)Lky/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (1083 available)
Il13^{tm1(YFP/cre)Lky} mutation (1 available); any Il13 mutation (25 available)
Il4^tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased eosinophil cell number ( J:178986 )

• in the lungs of mice infected with N. brasiliensis

increased susceptibility to parasitic infection ( J:178986 )

• mice exhibit reduced helminthes Nippostrongylus brasiliensis expulsion compared with control mice

hematopoietic system

decreased eosinophil cell number ( J:178986 )

• in the lungs of mice infected with N. brasiliensis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 2 cell differentiation ( J:138827 )

• CD4⁺ T cells fail to express IL-4 or GFP after in vitro activation under Th2 conditions and instead produce IFN-gamma (8%)

• these in vitro activated T cells also fail to upregulate mRNA encoding for IL-13, IL-5, IL-10, and GATA-3 proteins

• however, in vivo Th2 cell differentiation in response to a parasitic nematode infection is normal with Th2 cell numbers peaking at days 9-12 after primary infection and days 5-7 after secondary infection

• these Th2 cells upregulate mRNA encoding for IL-13, IL-5, and GATA-3 proteins

• normal in vivo Th2 cell differentiation is also observed in the Th2 priming models of allergic airway using either keyhole limpet hemocyanin or OVA sensitization, IgD neutralization, and intradermal ear injection of dead nematodes

impaired eosinophil recruitment ( J:138827 )

• eosinophil recruitment to the airways does not occur during infection with a parasitic nematode compared to controls which has a sizable migration for the first two weeks after primary and secondary infections

decreased IgE level ( J:138827 )

• serum IgE is absent 15 days after parasitic nematode infection compared to the 400 ng/ml present in controls

• serum IgE is also absent when the allergic airway model or the IgD neutralization model are induced

hematopoietic system

abnormal T-helper 2 cell differentiation ( J:138827 )

• CD4⁺ T cells fail to express IL-4 or GFP after in vitro activation under Th2 conditions and instead produce IFN-gamma (8%)

• these in vitro activated T cells also fail to upregulate mRNA encoding for IL-13, IL-5, IL-10, and GATA-3 proteins

• these Th2 cells upregulate mRNA encoding for IL-13, IL-5, and GATA-3 proteins

impaired eosinophil recruitment ( J:138827 )

decreased IgE level ( J:138827 )

• serum IgE is absent 15 days after parasitic nematode infection compared to the 400 ng/ml present in controls

• serum IgE is also absent when the allergic airway model or the IgD neutralization model are induced

Allelic Composition	Cigs2^tm1.1Anse/Cigs2⁺ Il4^tm1(CD2)Mmrs/Il4⁺
Genetic Background	involves: 129 * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cigs2^tm1.1Anse mutation (0 available); any Cigs2 mutation (0 available)
Il4^tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:181313 )

N	• following intraperitoneal injection of ovalbumin, mice exhibit normal IgG2b response compared with Il4^tm1(CD2)Mmrs heterozygotes • T cells and basophils exhibit normal Il13 production

decreased basophil cell number ( J:181313 )

• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation

decreased IgE level ( J:181313 )

• following intraperitoneal injection of ovalbumin as in Il4^tm1(CD2)Mmrs homozygotes

decreased IgG1 level ( J:181313 )

• following intraperitoneal injection of ovalbumin as in Il4^tm1(CD2)Mmrs homozygotes

decreased interleukin-4 secretion ( J:181313 )

• in Th2 polarized CD4+ T cells compared with Il4^tm1(CD2)Mmrs heterozygotes

• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin

• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation

hematopoietic system

decreased basophil cell number ( J:181313 )

• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation

decreased IgE level ( J:181313 )

• following intraperitoneal injection of ovalbumin as in Il4^tm1(CD2)Mmrs homozygotes

decreased IgG1 level ( J:181313 )

• following intraperitoneal injection of ovalbumin as in Il4^tm1(CD2)Mmrs homozygotes

Allelic Composition	Il13^tm1Anjm/Il13⁺ Il4^tm1.1Wep/Il4⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm1Anjm mutation (0 available); any Il13 mutation (25 available)
Il4^tm1.1Wep mutation (0 available); any Il4 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-4 secretion ( J:69099 )

• F1 crosses between mice homozygote for either allele creates offspring that has only one functional Il13 allele that is in cis with Il4^tm1.1Wep GFP reporter allele

• conversely, the one functional, wild-type Il4 allele is in cis with the null Il13^tm1Anjm allele

• CD4⁺ T cells from these mice primed in vitro under Th2 conditions have only 4.5% of T cells producing IL-4 compared to 14.8% of T cells producing IL-4 that are homozygous for wild-type Il13 and heterozygote for Il4^tm1.1Wep allele

• in contrast, GFP expression is similar in primed T cells from both sets of mice (5.9% and 6.8%)

• F1 crosses between 129 mice and Il4^tm1.1Wep homozygotes demonstrated the diminished IL-4 secretion was not the result of 129 polymorphisms in the Il4-Il13 genomic region

Allelic Composition	Il4^tm1Lky/Il4⁺ Lat^tm1.1Mal/Lat^tm1.1Mal
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Lky mutation (3 available); any Il4 mutation (41 available)
Lat^tm1.1Mal mutation (0 available); any Lat mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 2 physiology ( J:151840 )

• the first CD4⁺ T cells that seed the periphery in newborn mice undergo rapid expansion and convert into pathogenic Th2 effector cells

hematopoietic system

abnormal T-helper 2 physiology ( J:151840 )

• the first CD4⁺ T cells that seed the periphery in newborn mice undergo rapid expansion and convert into pathogenic Th2 effector cells

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