Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Cgh mutation
(3 available);
any
F2rl1 mutation
(58 available)
|
|
|
immune system
|
• mice fail to develop bone marrow-derived dendritic cells with to without soy bean trypsin inhibitor treatment unlike wild-type mice
• however, stimulation with TNG-alpha or by crosslinking CD40 results in mature dendritic cell development
|
hematopoietic system
|
• mice fail to develop bone marrow-derived dendritic cells with to without soy bean trypsin inhibitor treatment unlike wild-type mice
• however, stimulation with TNG-alpha or by crosslinking CD40 results in mature dendritic cell development
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Cgh mutation
(3 available);
any
F2rl1 mutation
(58 available)
|
|
|
integument
|
• mice exhibit faster recovery of the epidermal barrier compared to wild-type mice after acute barrier abrogation by tape stripping
(J:111734)
• unlike in wild-type mice, lamellar body secretion is enhanced prior to and following barrier abrogation
(J:111734)
• mice fail to exhibit apoptosis in stratum granulosum cells following tape stripping
(J:130935)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Cgh mutation
(3 available);
any
F2rl1 mutation
(58 available)
|
|
|
immune system
N |
• mice exhibit a normal response to endotoxin treatment
|
|
• following surgical trauma, mean leukocyte rolling flux fraction at 0 to 15 minutes is lower than in wild-type leukocytes and persists through 16 to 30 minutes but not after 30 minutes when mice exhibit an increase in the flux fraction
• following surgical trauma, rolling velocity at 0 to 15 minutes is increased compared to in wild-type leukocytes then decreases to normal after 15 minutes
|
|
• mice exhibit a resistance to antibody-induced crescentic glomerulonephritis with reduced crescent formation, protenuria, glomerular fibrin deposition, and serum creatinine compared to wild-type mice 21 days after induction
• however, following induction of crescentic glomerulonephritis, nephritogenic antiboe production, NO generation, inflammatory response and glomerular cell proliferation are normal
|
liver/biliary system
|
• the gallbladder fails to exhibit a normal short-circuit current response when stimulated with TFLLRN-NH2 and thrombin
• however, the short-circuit response to SLIGRL-NH2 and trypsin is normal
|
homeostasis/metabolism
renal/urinary system
|
• mice exhibit a resistance to antibody-induced crescentic glomerulonephritis with reduced crescent formation, protenuria, glomerular fibrin deposition, and serum creatinine compared to wild-type mice 21 days after induction
• however, following induction of crescentic glomerulonephritis, nephritogenic antiboe production, NO generation, inflammatory response and glomerular cell proliferation are normal
|
cellular
|
• following surgical trauma, mean leukocyte rolling flux fraction at 0 to 15 minutes is lower than in wild-type leukocytes and persists through 16 to 30 minutes but not after 30 minutes when mice exhibit an increase in the flux fraction
• following surgical trauma, rolling velocity at 0 to 15 minutes is increased compared to in wild-type leukocytes then decreases to normal after 15 minutes
|
hematopoietic system
|
• following surgical trauma, mean leukocyte rolling flux fraction at 0 to 15 minutes is lower than in wild-type leukocytes and persists through 16 to 30 minutes but not after 30 minutes when mice exhibit an increase in the flux fraction
• following surgical trauma, rolling velocity at 0 to 15 minutes is increased compared to in wild-type leukocytes then decreases to normal after 15 minutes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Cgh mutation
(3 available);
any
F2rl1 mutation
(58 available)
Spink5tm1Hov mutation
(0 available);
any
Spink5 mutation
(58 available)
|
|
|
mortality/aging
|
• mutants exhibit rapid lethality after birth due to severe dehydration
|
integument
|
• mutants exhibit vibrissae abnormalities
|
|
• mutants exhibit skin erosions
• double mutant skin grafted onto athymic immunodeficient nude mice appears erythematous, scaly, and has no hair, shows acanthosis with papillomatosis, hyperkeratosis, and parakeratosis and an increase in mast cells and polynuclear eosinophilic cells
|
|
• stratum corneum detachment
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Cgh mutation
(3 available);
any
F2rl1 mutation
(58 available)
Spint2Gt(KST272)Byg mutation
(0 available);
any
Spint2 mutation
(15 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Cgh mutation
(3 available);
any
F2rl1 mutation
(58 available)
Spint2Gt(KST272)Byg mutation
(0 available);
any
Spint2 mutation
(15 available)
St14tm1Bug mutation
(0 available);
any
St14 mutation
(44 available)
|
|
|
nervous system
|
• in all mice
• penetrance is identical to mutant mice wild-type for at least one F2rl1 allele
|
embryo
|
• neural tube defects are largely confined to the hindbrain region with only 5% showing involvement of the midbrain and none showing forebrain involvement
• defects generally only become obvious after E10.5
|
nervous system
|
• neural tube defects are largely confined to the hindbrain region with only 5% showing involvement of the midbrain and none showing forebrain involvement
• defects generally only become obvious after E10.5
|
limbs/digits/tail
mortality/aging
|
• female mice exhibit a decreased survival following exposure to endotoxin compared to wild-type mice
|
|
• only 5 % of expected mice are born and survive into adulthood to reproduce
|
|
• only 5% of expected mice were born
• however, surviving mice survive into adulthood
|
immune system
|
• female mice exhibit a decreased survival following exposure to endotoxin compared to wild-type mice and produce more cytokines at low doses of endotoxin
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Cgh mutation
(3 available);
any
F2rl1 mutation
(58 available)
Tg(KRT14-Prss8)2Hum mutation
(0 available)
|
|
|
integument
N |
• absence of F2rl1 completely rescued hyperplasia, barrier dysfunction, inflammation and ichthyosis
|