F2rl3^tm1Cgh
Targeted Allele Detail

Summary

• Symbol: F2rl3^tm1Cgh
• Name: F2R like thrombin or trypsin receptor 3; targeted mutation 1, Shaun R Coughlin
• MGI ID: MGI:2182916
• Synonyms: Par4^-
• Gene: F2rl3 Location: Chr8:73488508-73490502 bp, + strand Genetic Position: Chr8, 35.08 cM, cytoband B3.3
• Alliance: F2rl3^tm1Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71391
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing a lacZ gene followed by a floxed neo gene was inserted at the start codon in exon 1. RT-PCR and Northern blot analysis of splenic RNA showed an absence of transcript in homozygous mutant mice. Mice heterozygous for this allele were bred with transgenic mice bearing a constitutively expressed cre recombinase gene to generate F2rl3^tm1.1Cgh mice. (J:71391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2rl3 Mutation: 20 strains or lines available

References

• Original: J:71391 Sambrano GR, et al., Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature. 2001 Sep 6;413(6851):74-8
• All: 19 reference(s)