All Phenotypes Fgf18<tm1Sjt> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Fgf18^tm1Sjt/Fgf18^tm1Sjt
Genetic Background	B6.129S1-Fgf18^tm1Sjt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18^tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:157157 )

• mice die at birth

skeleton

abnormal rib morphology ( J:157157 )

• the ribs are slightly distorted

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:75880 )

• mice die just prior to or at birth

limbs/digits/tail

short radius ( J:75880 )

• decreased length

short ulna ( J:75880 )

• decreased length

abnormal fibula morphology ( J:75880 )

• incomplete ossification

short tibia ( J:75880 )

skeleton

short radius ( J:75880 )

• decreased length

short ulna ( J:75880 )

• decreased length

abnormal fibula morphology ( J:75880 )

• incomplete ossification

short tibia ( J:75880 )

abnormal rib morphology ( J:75880 )

• resulting in reduction of the volume of the thoracic cavity

kyphosis ( J:75880 )

• observed in the cervical and upper thoracic spine at E18.5

delayed bone ossification ( J:75880 )

• unossified areas of the calvaria were larger than those of wild-type

• decreased proliferation of calvarial osteogenic mesenchymal cells

• delay of terminal differentiation of the calvarial osteoblasts

• delay of osteogenic differentiation also observed

delayed cranial suture closure ( J:75880 )

• suture closure is delayed

growth/size/body

small thoracic cavity ( J:75880 )

respiratory system

abnormal lung vasculature morphology ( J:91986 )

• many embedded capillaries seen at E18.5, unlike in wild-type lungs where capillaries closely abutting alveolar spaces are observed

abnormal lung development ( J:91986 )

• impaired remodeling of the distal lung during the terminal saccular stage

• transient reduction in lung cell proliferation during the terminal saccular stage

• normal proximal and distal airway branching

• normal differentiation of lung epithelial cells at E18.5

abnormal lung saccule morphology ( J:91986 )

• significantly reduced alveolar spaces at E18.5

thick lung-associated mesenchyme ( J:91986 )

• thicker interstitial mesenchymal compartments at E18.5

small lung lobe ( J:91986 )

• all lung lobes are a little smaller than normal at E18.5

• however, number and orientation of lobes is normal

small lung ( J:91986 )

• slightly smaller lungs at E18.5

cardiovascular system

abnormal lung vasculature morphology ( J:91986 )

• many embedded capillaries seen at E18.5, unlike in wild-type lungs where capillaries closely abutting alveolar spaces are observed

Allelic Composition	Fgf18^tm1Sjt/Fgf18⁺ Glg1^{Gt(KST005)Byg}/Glg1⁺
Genetic Background	B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18^tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1^{Gt(KST005)Byg} mutation (1 available); any Glg1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:157157 )

• males are smaller at 1 month and females are smaller by 3 months

limbs/digits/tail

abnormal tail morphology ( J:157157 )

• males are smaller at 1 month and females are smaller by 3 months

Allelic Composition	Fgf18^tm1Sjt/Fgf18^tm1Sjt Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg}
Genetic Background	B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:157157 )

• mice die at birth

limbs/digits/tail

abnormal tail morphology ( J:157157 )

• tails of neonates are distorted

skeleton

abnormal rib morphology ( J:157157 )

• mice die at birth

abnormal spine curvature ( J:157157 )

• more severe curvature of the spine than Fgf18 null alone

Allelic Composition	Fgf18^tm1Sjt/Fgf18⁺ Glg1^{Gt(KST005)Byg}/Glg1^{Gt(KST005)Byg}
Genetic Background	B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:157157 )

• mortality is similar to Glg1 single mutants

limbs/digits/tail

abnormal tail morphology ( J:157157 )

• tails of neonates are distorted

skeleton

abnormal skeleton morphology ( J:157157 )

• skeletal deformities are similar to those in Glg1 single mutants

Allelic Composition	Fgf18^tm1Sjt/Fgf18^tm1Sjt Glg1^{Gt(KST005)Byg}/Glg1⁺
Genetic Background	B6.129-Glg1^{Gt(KST005)Byg} Fgf18^tm1Sjt

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:157157 )

• mice die at birth

skeleton

abnormal rib morphology ( J:157157 )

• mice die at birth

abnormal spine curvature ( J:157157 )

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