All Phenotypes Lefty1<tm1Hmd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lefty1^tm1Hmd/Lefty1^tm1Hmd	involves: 129P2/OlaHsd * C57BL/6Cr	MGI:3761090
cx2	Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Hmd/Lefty1^tm1Hmd Nodal^tm1Rob/Nodal⁺	involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1	MGI:3775813
cx3	Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Hmd/Lefty1^tm1Hmd	involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1	MGI:3775812
cx4	Lefty1^tm1Hmd/Lefty1^tm1Hmd Shisa2^tm1Sia/Shisa2^tm1Sia	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3718480
cx5	Lefty1^tm1Hmd/Lefty1^tm1Hmd Tg(Hhex-EGFP)#Rbe/0	involves: 129P2/OlaHsd * C57BL/6 * CBA/J	MGI:4949262

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:49052 )

• 50% of mice that are born die prior to weaning

embryonic lethality during organogenesis, incomplete penetrance ( J:49052 )

• 60% of embryos die between E10.5 and E13.5

cardiovascular system

right aortic arch ( J:49052 )

• in one mouse the arching of the aorta was reversed

abnormal vein morphology ( J:49052 )

abnormal left renal vein morphology ( J:49052 )

• some mice exhibit a left renal vein that is anterior to the right one

abnormal azygos vein morphology ( J:49052 )

• unlike in wild-type mice, the azygos vein is often reversed to the right or bilateral azygos veins are present on both sides and the azygos vein remains connected to the inferior vena cava without entering the liver

abnormal hepatic portal vein morphology ( J:49052 )

• some mice exhibit a portal vein that passes ventral to the duodenum

abnormal inferior vena cava morphology ( J:49052 )

• unlike in wild-type mice, the azygos vein remains connected to the inferior vena cava (IVC) and the abdominal portion of the IVC remains connected to the azygos without entering the liver

• in some mice the IVC is reversed on the right side or an IVC is present on each side

• mice exhibit abnormal branching of the IVC near the renal vein

abnormal cardiac outflow tract development ( J:49052 )

• mice exhibit malpositioning of the cardiac outflow tracts and other major vessels

abnormal heart morphology ( J:49052 )

• mice exhibit heart abnormalities such as transposition of the great vessels, double-outlet right ventricle, common artrioventricle canal, and tricuspid atresia

abnormal heart and great vessel attachment ( J:49052 )

• unlike in wild-type mice, mice exhibit a pulmonary artery that is dorsal to the aorta or side by side

• some mice exhibit an aorta that is ventral to the vena cava or a vena cava that is located to the left of the aorta

double outlet right ventricle ( J:49052 )

transposition of great arteries ( J:49052 )

• 9 of 12 hearts exhibit heart abnormalities such as transposition of great arteries, in which the pulmonary artery connects to the left ventricle and the aorta connects to the right ventricle, and double-outlet right ventricle

tricuspid valve atresia ( J:49052 )

atrial septal defect ( J:49052 )

abnormal heart position or orientation ( J:49052 )

• one mouse did not exhibit a levocardia apex position

left atrial isomerism ( J:49052 )

• the right atrium resembles the left atrium in some mice

complete atrioventricular septal defect ( J:49052 )

• frequently observed

ventricular septal defect ( J:49052 )

growth/size/body

left-sided isomerism ( J:49052 )

• most mice exhibit thoracic left-sided isomerism with malpositioning of the cardiac outflow tracts, the inferior vena cava and the azygos vein

left atrial isomerism ( J:49052 )

• the right atrium resembles the left atrium in some mice

left pulmonary isomerism ( J:49052 )

• mice exhibit left pulmonary isomerism consisting of bilateral monolobed lungs and left isomerism in the bronchi

• mice exhibit bilateral symmetry of the bronchi and bronchi are hyparterial

situs inversus ( J:49052 )

• in one mouse

respiratory system

left pulmonary isomerism ( J:49052 )

• mice exhibit left pulmonary isomerism consisting of bilateral monolobed lungs and left isomerism in the bronchi

• mice exhibit bilateral symmetry of the bronchi and bronchi are hyparterial

abnormal bronchus morphology ( J:49052 )

• mice exhibit left pulmonary isomerism consisting of bilateral monolobed lungs and left isomerism in the bronchi

• mice exhibit bilateral symmetry of the bronchi and bronchi are hyparterial

liver/biliary system

abnormal liver morphology ( J:49052 )

• defects in liver lobation (lack of caudate lobe and posterior sub-divisions of the right lateral lobe) are associated with azygos vein- inferior vena cava connections

renal/urinary system

abnormal left renal vein morphology ( J:49052 )

• some mice exhibit a left renal vein that is anterior to the right one

Allelic Composition	Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Hmd/Lefty1^tm1Hmd Nodal^tm1Rob/Nodal⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cer1^tm1Bhr mutation (0 available); any Cer1 mutation (11 available)
Lefty1^tm1Hmd mutation (1 available); any Lefty1 mutation (41 available)
Nodal^tm1Rob mutation (1 available); any Nodal mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:81339 )

• all triple mutant embryos at 7.5 dpc show morphological defects similar to or less severe than Cer1 Lefty1 double mutants

abnormal developmental patterning ( J:81339 )

abnormal embryonic tissue morphology ( J:81339 )

abnormal embryonic-extraembryonic boundary morphology ( J:81339 )

Allelic Composition	Cer1^tm1Bhr/Cer1^tm1Bhr Lefty1^tm1Hmd/Lefty1^tm1Hmd
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:81339 )

• by 9.5 dpc, 9.4% of embryos recovered are double nulls instead of expected 25%; surviving embryos are divided into classes I, II and III based on phenotypic characteristics

• Mendelian numbers are detected at 8.5 dpc

embryo

abnormal embryonic epiblast morphology ( J:81339 )

• at 6.5 dpc, abnormalities can be observed, such as an accumulation of visceral endoderm cells at the presumptive anterior pole of the embryo

• abnormal thickening of the proximal anterior epiblast is observed and perisists to 7.5 dpc

• in some class II and III embryos, anterior and/or lateral protrusions ectoderm protrusions contact the opposite side of the ectoderm, leading to pinching of the embryonic region separating it into two or three distinct embryonic axes at 8.5 and 9.5 dpc

abnormal lateral plate mesoderm morphology ( J:81339 )

• class I and II mutants have severely reduced amounts of lateral mesoderm cells

abnormal paraxial mesoderm morphology ( J:81339 )

• in class I and II mutants, paraxial mesoderm precursors are absent or misspecified

abnormal primitive streak morphology ( J:81339 )

• class III double mutants develop multiple primitive streaks at 8.5 and 9.5 dpc; ectopic primitive streak initiation begins later than the endogenous streak

abnormal primitive streak formation ( J:81339 )

• expansion of the anterior primitive streak and its derivatives is observed in class I and II embryos at 7.5 dpc; anterior definitive endoderm is expanded in class I mutant embryos

• at 7.5 dpc in class II mutants, visceral endoderm cells persist in the anterior embryonic region

absent somites ( J:81339 )

• somites are not observed in some class III mutants at 8.5 and 9.5 dpc

embryonic-extraembryonic boundary constriction ( J:81339 )

• class II and III double null embryos (29% of total) show separation of embryonic and extraembryonic regions by a tight constriction, resulting in physical separation of embryonic and extraembryonic ectoderm

abnormal amniotic cavity morphology ( J:81339 )

• in some double null embryos, accumulation of pyknotic cells arising from the ectodermal protrusions is observed in the amniotic cavity

Allelic Composition	Lefty1^tm1Hmd/Lefty1^tm1Hmd Shisa2^tm1Sia/Shisa2^tm1Sia
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty1^tm1Hmd mutation (1 available); any Lefty1 mutation (41 available)
Shisa2^tm1Sia mutation (0 available); any Shisa2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:122557 )

N	• no defects in anterior neuroectoderm development are detected

Allelic Composition	Lefty1^tm1Hmd/Lefty1^tm1Hmd Tg(Hhex-EGFP)#Rbe/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty1^tm1Hmd mutation (1 available); any Lefty1 mutation (41 available)
Tg(Hhex-EGFP)#Rbe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal anterior visceral endoderm cell migration ( J:170681 )

• 5 of 7 mice exhibit an anterior visceral endoderm (AVE) migration defect (1 arrested migration; 4 over-migration) compared with wild-type mice

• 5 of 13 mice exhibit mild AVE migration defects (1 slight delay; 4 slight over-migration) compared with wild-type mice

cellular

abnormal anterior visceral endoderm cell migration ( J:170681 )

• 5 of 7 mice exhibit an anterior visceral endoderm (AVE) migration defect (1 arrested migration; 4 over-migration) compared with wild-type mice

• 5 of 13 mice exhibit mild AVE migration defects (1 slight delay; 4 slight over-migration) compared with wild-type mice

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