Phenotypes associated with this allele

• Allele Symbol: Omp^tm1Mom
• Allele Name: targeted mutation 1, Peter Mombaerts
• Allele ID: MGI:2179520
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ebf2^tm2.1(Zfp423)Reed/Ebf2^+ Omp^tm1Mom/Omp^+	involves: 129S2/SvPas	MGI:3714637
cx2	Omp^tm1Mom/Omp^+ Zfp423^tm1Reed/Zfp423^tm1Reed	involves: 129S2/SvPas	MGI:3714641
cx3	Adcy3^tm1Drs/Adcy3^tm1Drs Omp^tm1Mom/Omp^+	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3714863

Genotype
MGI:3714637

cx1

• Allelic Composition: Ebf2^{tm2.1(Zfp423)Reed}/Ebf2⁺; Omp^tm1Mom/Omp⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

Genotype
MGI:3714641

cx2

• Allelic Composition: Omp^tm1Mom/Omp⁺; Zfp423^tm1Reed/Zfp423^tm1Reed
• Genetic Background: involves: 129S2/SvPas

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

Genotype
MGI:3714863

cx3

• Allelic Composition: Adcy3^tm1Drs/Adcy3^tm1Drs; Omp^tm1Mom/Omp⁺
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

nervous system

abnormal olfactory bulb morphology ( J:122528 )

• most glomeruli, including those in the necklace and Grueneberg, are reduced and loosely organized

• however, epithelia have normal amounts of mature olfactory sensory neurons

abnormal olfactory nerve morphology ( J:122528 )

• from P15, Omp+ mature neurons are absent from the dorsocaudal part of the olfactory bulb