Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm1Pec mutation
(0 available);
any
Hif1a mutation
(48 available)
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embryo
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• E9.5 embryos display developmental arrest and morphological phenotypes identical to those previously reported for other genetic backgrounds
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm1Pec mutation
(0 available);
any
Hif1a mutation
(48 available)
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mortality/aging
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• embryos with cardia bifida die around E9.5-E10
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growth/size/body
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• growth retarded after E8.5
• embryos with heart looping defects are less retarded than embryos with cardia bifida
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cardiovascular system
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• embryonic angiogenesis is impaired, however differentiation of angioblasts to endothelial cells and their subsequent assembly into a primary vascular labyrinth in the yolk sac and embryo proper at E8.5 occurs, indicating that vasculogenesis occurs
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• distal dorsal aorta is regressed in homozygotes but not wild-type
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• vitelline artery and distal dorsal aorta are regressed in homozygotes but not wild-type
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• myocardial trabeculation is significantly retarded in half or absent in the other half of E9.5 embryos, however cardiomyocytes differentiate normally in E9.5 embryos
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• myocardial trabeculation is absent in half of E9.5 embryos
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• cardiac development at E9.5 is severely abnormal
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• in embryos that do form a single heart tube, primitive hearts fail to loop at all or looping occurs abnormally
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• about 32% exhibit cardia bifida as the cardiac crescent fails to form and results in the development of two separate myocardial tubes, each lined by endocardial cells
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• defective ventricle formation
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embryo
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• neural crest cells are abnormally distributed as early as E8.75, indicating impaired migration
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• defective formation of pharyngeal arches
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• the second pharyngeal arch is either small or absent
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• the second pharyngeal arch is either small or absent
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• growth retarded after E8.5
• embryos with heart looping defects are less retarded than embryos with cardia bifida
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• head folds fail to close at E9.5
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• remodeling of the immature capillary plexus into a mature vascular bed is disturbed
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nervous system
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• head folds fail to close at E9.5
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craniofacial
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• defective formation of pharyngeal arches
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• the second pharyngeal arch is either small or absent
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• the second pharyngeal arch is either small or absent
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muscle
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• myocardial trabeculation is significantly retarded in half or absent in the other half of E9.5 embryos, however cardiomyocytes differentiate normally in E9.5 embryos
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• myocardial trabeculation is absent in half of E9.5 embryos
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homeostasis/metabolism
cellular
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• vitelline artery and distal dorsal aorta are regressed in homozygotes but not wild-type
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• neural crest cells are abnormally distributed as early as E8.75, indicating impaired migration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln2tm1Pec mutation
(0 available);
any
Egln2 mutation
(18 available)
Hif1atm1Pec mutation
(0 available);
any
Hif1a mutation
(48 available)
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muscle
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• double mutants show ischemic muscle damage that is intermediate to Egln2/Epas1 double mutants and Egln2-null mice, so protection is partially lost in these animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln3tm1Pjr mutation
(0 available);
any
Egln3 mutation
(24 available)
Hif1atm1Pec mutation
(0 available);
any
Hif1a mutation
(48 available)
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nervous system
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• the number of neurons is similar to that in mice homozygous for Egln3tm1Pjr alone
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• the nerve growth factor dose-response survival curve of superior cervical ganglia neurons is not significantly different from that of neurons homozygous for Egln3tm1Pjr alone
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Analysis Tools
