Egln3^tm1Pjr
Targeted Allele Detail

Summary

• Symbol: Egln3^tm1Pjr
• Name: egl-9 family hypoxia-inducible factor 3; targeted mutation 1, Peter J Ratcliffe
• MGI ID: MGI:3795244
• Synonyms: PHD3^-
• Gene: Egln3 Location: Chr12:54225767-54250646 bp, - strand Genetic Position: Chr12, 22.9 cM
• Alliance: Egln3^tm1Pjr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136034
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:136034)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln3 Mutation: 24 strains or lines available

References

• Original: J:136034 Bishop T, et al., Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Mol Cell Biol. 2008 May;28(10):3386-400
• All: 10 reference(s)