Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1tm1(cre)Rth mutation
(1 available);
any
Olig1 mutation
(13 available)
|
|
|
nervous system
|
N |
• cortical volume like controls
• no significant increase in inhibitory activity on pyramidal cells
|
|
|
• 35% increase in interneuron precursor cells expressing parvalbumin and calretinin but not neuropeptide-Y or somatostatin
• 30% increase in cells expressing GABA and GAD67
|
|
|
• increase in parvalbumin interneuron synapse on cortical pyramidal neurons
|
|
|
• increased interneuron production in the olfactory bulb
|
|
|
• increased interneuron production
|
|
|
• in the corpus callosum, motor cortex, and cerebellar white matter at 21 and 50 days of age
• also reduced in the ventral telencephalon where there is a 30% increase of interneurons
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1tm1(cre)Rth mutation
(1 available);
any
Olig1 mutation
(13 available)
|
|
|
nervous system
|
|
• markers of oligodendrocyte progenitors in the white matter of the spinal cord are delayed, suggesting that maturation of oligodendrocytes in mutants is affected
|
nervous system
|
|
• lower percentage of CC1+ differentiating oligodendrocytes amongst Olig2+ oligodendrocytes in brain at age P7
• lower number of Mbp+ mature oligodendrocytes in brain at age P7
|
|
|
• reduced myelination of axons in optic nerves at age P15
• thinner myelin sheaths around axons in optic nerves at age P15
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Sud mutation
(0 available);
any
Ncstn mutation
(33 available)
Olig1tm1(cre)Rth mutation
(1 available);
any
Olig1 mutation
(13 available)
|
|
|
behavior/neurological
|
|
• mice exhibit increased exploratory behavior in both the open field and elevated plus maze
|
|
|
• compulsive grooming in symptomatic mice
• presymptomatic mice show a trend towards excessive grooming
|
|
|
• mice are hyperactive in both the open field and elevated plus maze
• treatment with an acute intraperitoneal injection of a low dose of haloperidol reverses the hyperactivity but does not alter the thigmotaxis in the open field maze
|
|
|
• mice exhibit trichotillomania
|
integument
|
|
• aged mice exhibit extensive bald patches localized to the nape of the neck and upper back
|
|
|
• bald patches progress to full lesions with 100% penetrance by 9 months of age
• lesions are self-inflicted and not caused by social grooming
• lesions are not responsive to topical antibiotic, anti-inflammatory, or antihistamine treatment and mice do not exhibit a difference in response to histamine injection compared to controls
|
nervous system
|
|
• thinner myelin sheaths in the optic nerve, indicating hypomyelination in the optic nerve
• however, myelination in the spinal cord and sciatic nerve is normal
|
|
|
• hypomyelination in the optic nerve
|
|
|
• mice are less sensitive to the prepulse and thus show reduced inhibition
|
mortality/aging
|
|
• double heterozygotes are viable to E18.0 but no live mice are recovered
|
nervous system
|
|
• oligodendrocytes cannot be detected in mutant embryos examined from
E12.5-18
|
|
|
• at E10.0, few motor neurons are detectable in the ventral spinal cord compared to wild-type; this result is consistent from E10.5-14
|
nervous system
|
|
• decrease in the number of MBP+ oligodendrocytes in the spinal cord
• decrease in the number of CC1+ oligodendrocytes and oligodendrocyte lineage cells in the cortices
• number of CC1+ oligodendrocytes increases with age, eventually reaching control levels in the spinal cord
|
|
|
• at P28 in the optic nerve
|
|
|
• decrease in the number of myelinated axons at P14 in the optic nerve
• degree of hypomyelination decreases with age with no difference detected in the spinal cord at P60
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1tm1(cre)Rth mutation
(1 available);
any
Olig1 mutation
(13 available)
Seh1ltm1Lzha mutation
(0 available);
any
Seh1l mutation
(84 available)
|
|
|
mortality/aging
|
|
• mice die during the third postnatal week
|
behavior/neurological
|
|
• mice develop tremors from postnatal week 2
|
|
|
• mice develop ataxia from postnatal week 2
|
|
|
• mice develop seizures from postnatal week 2
|
nervous system
|
|
• mice develop seizures from postnatal week 2
|
|
|
• oligodendrocyte progenitor cells do not differentiate into MBP+, CNP+ oligodendrocytes after tri-iodothyronine induction, indicating oligodendrocyte progenitor cell differentiation defects
|
|
|
• reduction of mature oligodendrocytes
• however, oligodendrocyte progenitor cell markers are detected in the spinal cord and brain at P4, P7, and P14 and oligodendrocyte progenitor cell proliferation rates are normal and markers of mature neurons, astrocytes, and microglia are similar to wild-type
|
|
|
• optic nerve is translucent indicating a deficiency of myelin formation
• myelinated axons are hardly detectable in the optic nerve, corpus callosum, or spinal cord at P14
|
cellular
|
|
• oligodendrocyte progenitor cells do not differentiate into MBP+, CNP+ oligodendrocytes after tri-iodothyronine induction, indicating oligodendrocyte progenitor cell differentiation defects
|
mortality/aging
|
|
• mice fail to thrive and tend to die in the neonatal period
|
|
|
• mice are always dead before 21 days of age
|
mortality/aging
|
N |
• mice survive to adulthood
|
nervous system
|
N |
• interneuron numbers tend to be more normal
|
Analysis Tools