About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh5tm1Htr
targeted mutation 1, Hein te Riele
MGI:2179022
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msh5tm1Htr/Msh5tm1Htr involves: 129P2/OlaHsd * FVB MGI:2664158


Genotype
MGI:2664158
hm1
Allelic
Composition		 Msh5tm1Htr/Msh5tm1Htr
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh5tm1Htr mutation (0 available); any Msh5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent oocytes ( J:53516 )
• absence of oocytes
azoospermia ( J:53516 )
• no spermatozoa in the caudal epididymis
increased male germ cell apoptosis ( J:53516 )
• increased apoptosis of spermatocytes
small ovary ( J:53516 )
• rudimentary appearance
decreased testis weight ( J:53516 )
• 70% weight reduction
increased granulosa cell tumor incidence ( J:180025 )
• tumors show a consistent pattern of DNA copy number aberrations
abnormal female meiosis ( J:53516 )
• defective synaptonemal complex formation
arrest of male meiosis ( J:53516 )
• arrest at the zygotene stage, characterized by improper synaptonemal complex formation and frequent non-homologous synapsis

cellular
absent oocytes ( J:53516 )
• absence of oocytes
azoospermia ( J:53516 )
• no spermatozoa in the caudal epididymis
increased male germ cell apoptosis ( J:53516 )
• increased apoptosis of spermatocytes

endocrine/exocrine glands
small ovary ( J:53516 )
• rudimentary appearance
decreased testis weight ( J:53516 )
• 70% weight reduction
increased granulosa cell tumor incidence ( J:180025 )
• tumors show a consistent pattern of DNA copy number aberrations

neoplasm
increased granulosa cell tumor incidence ( J:180025 )
• tumors show a consistent pattern of DNA copy number aberrations




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory