About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Jak2tm1Jni
targeted mutation 1, James N Ihle
MGI:2178844
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Jak2tm1Jni/Jak2tm1Jni involves: 129P2/OlaHsd MGI:3583267
ht2
 		Jak2tm1Jni/Jak2+ involves: 129P2/OlaHsd MGI:5562427
ht3
 		Jak2m1Dlbr/Jak2tm1Jni involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J MGI:5562428


Genotype
MGI:3583267
hm1
Allelic
Composition		 Jak2tm1Jni/Jak2tm1Jni
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1Jni mutation (0 available); any Jak2 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:207740 )
• although present at E12.5, no viable mice are present at E14.5
prenatal lethality, complete penetrance ( J:47299 )
• embryonic death at some time after E10-E12

hematopoietic system
abnormal megakaryocyte differentiation ( J:47299 )
• failure of precursor cells to respond to thrombopoietin
abnormal erythropoiesis ( J:47299 )
• failure of precursors to respond to erythropoietin
extramedullary hematopoiesis ( J:47299 )
• failure of hematopoiesis in the fetal liver
anemia ( J:207740 )
• at E12.5

cellular
abnormal megakaryocyte differentiation ( J:47299 )
• failure of precursor cells to respond to thrombopoietin




Genotype
MGI:5562427
ht2
Allelic
Composition		 Jak2tm1Jni/Jak2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1Jni mutation (0 available); any Jak2 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:207740 )
N
• bone marrow exhibits normal CFU-megakaryocyte assays
• mice exhibit normal response to 5-fluorouracil and phenylhydrazine challenge
decreased erythrocyte cell number ( J:207740 )
• in male, but not female, mice




Genotype
MGI:5562428
ht3
Allelic
Composition		 Jak2m1Dlbr/Jak2tm1Jni
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2m1Dlbr mutation (0 available); any Jak2 mutation (57 available)
Jak2tm1Jni mutation (0 available); any Jak2 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
anemia ( J:207740 )
• at E12.5 and E14.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory