Phenotypes associated with this allele

• Allele Symbol: Rev3l^tm1Kaji
• Allele Name: targeted mutation 1, Kagemasa Kajiwara
• Allele ID: MGI:2178815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rev3l^tm1Kaji/Rev3l^tm1Kaji	involves: 129P2/OlaHsd * C57BL/6J	MGI:3840870

Genotype
MGI:3840870

hm1

• Allelic Composition: Rev3l^tm1Kaji/Rev3l^tm1Kaji
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:74111 )

• mutant embryos are not seen after E10.0, and some appear to be undergoing resorbtion as early as E8.5

cellular

increased embryonic tissue cell apoptosis ( J:74111 )

• by E8.5, mutant embryos show considerable apoptotic cell death in the embryo proper

embryo

increased embryonic tissue cell apoptosis ( J:74111 )

• by E8.5, mutant embryos show considerable apoptotic cell death in the embryo proper

embryonic growth arrest ( J:74111 )

• by E8.5

abnormal embryonic tissue morphology ( J:74111 )

• abnormalities are seen in mutant embryos beginning at E7.5, when apoptotic cells are detectable in the embryo proper

• by E8.5, mutant embryos show growth arrest and considerable apoptotic cell death in the embryo proper

• by E9.5-E10, 50% of the mutant embryos are undergoing resorbtion, with the remainder showing severe abnormalites