Phenotypes associated with this allele

• Allele Symbol: Lmx1b^Icst
• Allele Name: iris-corneal strands
• Allele ID: MGI:2178439
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmx1b^Icst/Lmx1b^Icst	involves: BALB/cAnN * C3H/HeN	MGI:5605660
ht2	Lmx1b^Icst/Lmx1b^+	involves: BALB/cAnN * C3H/HeN	MGI:2686914

Genotype
MGI:5605660

hm1

• Allelic Composition: Lmx1b^Icst/Lmx1b^Icst
• Genetic Background: involves: BALB/cAnN * C3H/HeN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:215517 )

nervous system

absent cerebellum ( J:215517 )

renal/urinary system

abnormal kidney morphology ( J:215517 )

abnormal podocyte morphology ( J:215517 )

• undeveloped

limbs/digits/tail

abnormal limb position ( J:215517 )

• ventralized limbs

Genotype
MGI:2686914

ht2

• Allelic Composition: Lmx1b^Icst/Lmx1b⁺
• Genetic Background: involves: BALB/cAnN * C3H/HeN

mortality/aging

perinatal lethality, incomplete penetrance ( J:215517 )

vision/eye

abnormal eye morphology ( J:75964 )

corneal vascularization ( J:215517 )

• neovascularization

abnormal optic nerve morphology ( J:215517 )

• nerve damage with progressive loss of axons

abnormal iridocorneal angle ( J:215517 )

• closed or open but narrowed angle

abnormal iris morphology ( J:75964 , J:215517 )

• other iris abnormalities noted such as membrane, bands or ectropian uveae (J:75964)

• flattened endothelial cells migrate onto the anterior surface of the iris (J:215517)

irregularly shaped pupil ( J:75964 )

• incomplete penetrance, incidence noted in 53% of animals

anterior iris synechia ( J:75964 , J:215517 )

• described as iris corneal adhesion with incomplete penetrance, incidence noted in 32% of animals (J:75964)

abnormal Descemet membrane morphology ( J:215517 )

• wrinkled

abnormal corneal endothelium morphology ( J:75964 , J:215517 )

• proliferation of corneal endothelial cells was noted (J:75964)

cornea ulcer ( J:215517 )

corneal opacity ( J:75964 , J:215517 )

• described as corneal haze with incomplete penetrance, incidence noted in 51% of animals (J:75964)

corneal scarring ( J:75964 , J:215517 )

macrophthalmia ( J:75964 )

• noted in older mice, possibly due to glaucoma

buphthalmos ( J:215517 )

• by 6-8 weeks of age

ocular hypertension ( J:215517 )

• elevated intraocular pressure in 35% of mice

cardiovascular system

corneal vascularization ( J:215517 )

• neovascularization

nervous system

abnormal optic nerve morphology ( J:215517 )

• nerve damage with progressive loss of axons

renal/urinary system

abnormal renal glomerulus morphology ( J:215517 )

• variable