All Phenotypes Tmem98<Rwhs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tmem98^Rwhs
retinal white spots
MGI:2178433

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem98^Rwhs/Tmem98^Rwhs	involves: BALB/cAnN * C3H/HeN	MGI:3028502
hm2	Tmem98^Rwhs/Tmem98^Rwhs	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:6358113
ht3	Tmem98^Rwhs/Tmem98⁺	involves: BALB/cAnN * C3H/HeN	MGI:3028503
ht4	Tmem98^Rwhs/Tmem98⁺	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:6358112
ht5	Tmem98^em2Jkn/Tmem98^Rwhs	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:6358121
ht6	Tmem98^em1Jkn/Tmem98^Rwhs	involves: BALB/cAnN * C3H/HeN * C57BL/6J	MGI:6358122
ht7	Tmem98^{tm1b(EUCOMM)Wtsi}/Tmem98^Rwhs	involves: BALB/cAnN * C3H/HeN * C57BL/6N	MGI:6358125

Allelic Composition	Tmem98^Rwhs/Tmem98^Rwhs
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98^Rwhs mutation (2 available); any Tmem98 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

disorganized retina layers ( J:75964 )

• discrete, focal invaginations of the photoreceptors and outer nuclear layer are present that impinge on the more superficial retinal layers

retina spots ( J:75964 )

• the retina is described as being covered with pale spots; age of onset is 6 to 12 weeks; the number of spots increases with time

Allelic Composition	Tmem98^Rwhs/Tmem98^Rwhs
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98^Rwhs mutation (2 available); any Tmem98 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:277123 )

• expected Mendelian ratio found between E16.5-E17.5 but homozygous KO pups die between birth and weaning

pigmentation

abnormal iris pigmentation ( J:277123 )

• scattered white spots

vision/eye

abnormal iris pigmentation ( J:277123 )

• scattered white spots

abnormal retina outer nuclear layer morphology ( J:277123 )

• folds in outer nuclear layer

Allelic Composition	Tmem98^Rwhs/Tmem98⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98^Rwhs mutation (2 available); any Tmem98 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

disorganized retina layers ( J:75964 )

• discrete, focal invaginations of the photoreceptors and outer nuclear layer are present that impinge on the more superficial retinal layers

retina spots ( J:75964 )

• the retina is described as being covered with pale spots; age of onset is 6 to 12 weeks; the number of spots increases with time

Allelic Composition	Tmem98^Rwhs/Tmem98⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98^Rwhs mutation (2 available); any Tmem98 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:277123 )

• viable

reproductive system

reproductive system phenotype ( J:277123 )

• fertile

vision/eye

vision/eye phenotype ( J:277123 )

N	• normal a-wave and b-wave amplitudes

Allelic Composition	Tmem98^em2Jkn/Tmem98^Rwhs
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98^em2Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98^Rwhs mutation (2 available); any Tmem98 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal iris pigmentation ( J:277123 )

• progressive appearance of white spots

vision/eye

abnormal iris pigmentation ( J:277123 )

• progressive appearance of white spots

abnormal retina outer nuclear layer morphology ( J:277123 )

• folds in outer nuclear layer

Allelic Composition	Tmem98^em1Jkn/Tmem98^Rwhs
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98^em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98^Rwhs mutation (2 available); any Tmem98 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal iris pigmentation ( J:277123 )

• progressive appearance of white spots

vision/eye

abnormal iris pigmentation ( J:277123 )

• progressive appearance of white spots

abnormal retina outer nuclear layer morphology ( J:277123 )

• folds in outer nuclear layer

Allelic Composition	Tmem98^{tm1b(EUCOMM)Wtsi}/Tmem98^Rwhs
Genetic Background	involves: BALB/cAnN * C3H/HeN * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98^Rwhs mutation (2 available); any Tmem98 mutation (25 available)
Tmem98^{tm1b(EUCOMM)Wtsi} mutation (0 available); any Tmem98 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:277123 )

• viable

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