Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mycntm1Fwa mutation
(0 available);
any
Mycn mutation
(24 available)
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liver/biliary system
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• at E11.5, but not at E10.5, all mutant embryos show a 50-fold increase in hepatocyte apoptosis relative to wild-type controls
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• at E11.5, mutant livers are smaller, consist of only one lobe, and show a 2-fold reduction in the number of hematopoietic cells
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• failure of mutant livers to develop into a multi-lobular organ
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• at E11.5, mutant livers are smaller than wild-type
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• at E11.5, mutant livers are less densely populated than wild-type
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hematopoietic system
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• at E11.5, mutant livers show a 2-fold reduction in the number of hematopoietic cells relative to wild-type controls
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cellular
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• at E11.5, but not at E10.5, all mutant embryos show a 50-fold increase in hepatocyte apoptosis relative to wild-type controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mycntm1Fwa mutation
(0 available);
any
Mycn mutation
(24 available)
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mortality/aging
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• homozygotes die between E10.5 and E12.5, probably due to heart failure
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cardiovascular system
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• at E11.5, two of 3 mutant embryos display an enlarged or dilated anterior cardinal vein
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• at E10.5 and E11.5, some mutant embryos display reduced trabeculation of the ventricles
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• at E10.5 and E11.5, the endocardium is still present in some embryos, indicating failure to undergo epithelial-mesenchymal transformation
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• at E9.5, the ventricular region has not yet divided into chambers and trabeculation of the ventricle is reduced, unlike in wild-type hearts
• at E10.5, all mutant hearts appear significantly underdeveloped
• at E10.5, all mutant hearts retain the S-shape typical of E9.5 wild-type hearts; also seen in 1 of 3 mutant hearts at E11.5
• at E11.5, some mutant hearts contain atria and ventricular chambers but show underdeveloped valvular and septal tissues and trabecula carnea
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embryo
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• homozygous mutant embryos are often, but not always, reduced in size
• at E9.5-E11.5, three of 12 mutant embryos show severely reduced cellularity, as reflected by the amount of extractable RNA
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• at E10.5, the number of mesonephric tubules is reduced
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• at E11.5, some mutant embryos display irregularity and reduced cellularity in the neural ectoderm of the telencephalon and the myelencephalon
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growth/size/body
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• homozygous mutant embryos are often, but not always, reduced in size
• at E9.5-E11.5, three of 12 mutant embryos show severely reduced cellularity, as reflected by the amount of extractable RNA
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nervous system
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• at E11.5, some mutant embryos display irregularity and reduced cellularity in the neural ectoderm of the telencephalon and the myelencephalon
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• at E10.5 and E11.5, mutant cranial ganglia, including the acoustico-facialis ganglia, are reduced in size and cellularity
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• at E10.5 and E11.5, mutant trigeminal ganglia are reduced in size and cellularity
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• at E10.5 and E11.5, mutant spinal ganglia are reduced in size
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• at E10.5 and E11.5, mutant spinal ganglia show reduced cellularity
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muscle
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• at E10.5 and E11.5, some mutant embryos display reduced trabeculation of the ventricles
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vision/eye
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• invagination of the lens vesicles is slightly delayed but normal
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• invagination of the optic vesicles is slightly delayed but normal
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Analysis Tools