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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxd12+
wild type
MGI:2178063
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Hoxd12tm1Mrc/Hoxd12+ involves: 129S7/SvEvBrd MGI:3513033
cx2
 		Hoxd12tm2Ddu/Hoxd12+
Hoxd13tm1Ddu/Hoxd13+ 		either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6) MGI:2178077


Genotype
MGI:3513033
ht1
Allelic
Composition		 Hoxd12tm1Mrc/Hoxd12+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd12tm1Mrc mutation (0 available); any Hoxd12 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal digit morphology ( J:32603 )
• the autopods of heterozygotes appear normal except for the appearance at low penetrance (~6%) of a tiny bony element located postaxially to digit V




Genotype
MGI:2178077
cx2
Allelic
Composition		 Hoxd12tm2Ddu/Hoxd12+
Hoxd13tm1Ddu/Hoxd13+
Genetic
Background		 either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd12tm2Ddu mutation (1 available); any Hoxd12 mutation (14 available)
Hoxd13tm1Ddu mutation (0 available); any Hoxd13 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal digit morphology ( J:36770 )
• postminimus in 80% of trans-heterozygous mice
brachyphalangia ( J:36770 )
• reduction in digit size of trans-heterozygous mice is most prominent in the second phalanges
brachydactyly ( J:36770 )
• trans-heterozygous mice exhibit a reduction of digits V and II in the forelimbs

skeleton
brachyphalangia ( J:36770 )
• reduction in digit size of trans-heterozygous mice is most prominent in the second phalanges




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory