Phenotypes associated with this allele

• Allele Symbol: Kit^tm1.1Bsm
• Allele Name: targeted mutation 1.1, Peter Besmer
• Allele ID: MGI:2178059
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^tm1.1Bsm/Kit^tm1.1Bsm	B6.129S1-Kit^tm1.1Bsm	MGI:4358483
hm2	Kit^tm1.1Bsm/Kit^tm1.1Bsm	involves: 129S1/Sv * BALB/c * C57BL/6J * FVB/N	MGI:3813587
hm3	Kit^tm1.1Bsm/Kit^tm1.1Bsm	involves: 129S1/Sv * C57BL/6J	MGI:4358555
ht4	Kit^tm1.1Bsm/Kit^W	involves: 129S1/Sv * C57BL/6	MGI:4358485
cx5	Il2rg^tm1Cgn/Il2rg^tm1Cgn Kit^tm1.1Bsm/Kit^tm1.1Bsm	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:4358484

Genotype
MGI:4358483

hm1

• Allelic Composition: Kit^tm1.1Bsm/Kit^tm1.1Bsm
• Genetic Background: B6.129S1-Kit^tm1.1Bsm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

arrest of spermatogenesis ( J:90485 )

♂ • spermatogenesis is blocked at the spermatogonial stages

hematopoietic system

hematopoietic system phenotype ( J:90485 )

N • hematocrit values and red blood cell, white blood cell, and platelet numbers are normal

pigmentation

pigmentation phenotype ( J:90485 )

N • coat pigmentation is normal

immune system

immune system phenotype ( J:90485 )

N • pro B and T cell development are normal

Genotype
MGI:3813587

hm2

• Allelic Composition: Kit^tm1.1Bsm/Kit^tm1.1Bsm
• Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6J * FVB/N

cellular

decreased male germ cell number ( J:61141 )

♂ • germ cells that fail to enter into meiosis at P10 undergo apoptosis and by P21 few germs cells remain in the seminiferous tubules

growth/size/body

ovary hyperplasia ( J:61141 )

♀

ovary cyst ( J:61141 )

♀

reproductive system

reproductive system phenotype ( J:61141 )

N • unlike in other Kit mutants, primordial germ cells survive, proliferate and migrate normally

decreased male germ cell number ( J:61141 )

♂ • germ cells that fail to enter into meiosis at P10 undergo apoptosis and by P21 few germs cells remain in the seminiferous tubules

abnormal ovary morphology ( J:61141 )

♀ • mice exhibit ovarian tubule hyperplasia

decreased secondary ovarian follicle number ( J:61141 )

♀ • number of pre-antral follicle cells is reduced compared to in wild-type mice

decreased tertiary ovarian follicle number ( J:61141 )

♀ • number of antral follicle cells is reduced compared to in wild-type mice

impaired ovarian folliculogenesis ( J:61141 )

♀ • follicle development is impaired at the cuboidal stages

♀ • however, some oocytes undergo maturation

ovary hyperplasia ( J:61141 )

♀

ovary cyst ( J:61141 )

♀

increased Leydig cell number ( J:61141 )

♂

arrest of spermatogenesis ( J:61141 )

♂ • at P10, germ cells fail to enter meiosis

reduced female fertility ( J:61141 )

♀

male infertility ( J:61141 )

♂

immune system

decreased mast cell number ( J:61141 )

• the number of mast cells in the peritoneal cavity is reduced 3.5-fold compared to in wild-type mice

• however, mice exhibit a normal number of mast cells in dorsal skin sections

abnormal mast cell physiology ( J:61141 )

• mast cells exhibit a 40% to 60% drop in apoptosis following treatment with steel factor/ mass cell growth factor (KL/Mgf) compared to similarly treated wild-type mice

homeostasis/metabolism

increased circulating luteinizing hormone level ( J:61141 )

• 7-fold compared to in wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:61141 )

N • unlike in other Kit mutants, mice exhibit normal steady state hematopoiesis

decreased mast cell number ( J:61141 )

• the number of mast cells in the peritoneal cavity is reduced 3.5-fold compared to in wild-type mice

• however, mice exhibit a normal number of mast cells in dorsal skin sections

abnormal mast cell physiology ( J:61141 )

• mast cells exhibit a 40% to 60% drop in apoptosis following treatment with steel factor/ mass cell growth factor (KL/Mgf) compared to similarly treated wild-type mice

pigmentation

pigmentation phenotype ( J:61141 )

N • unlike in other Kit mutants, melanogenesis is normal

endocrine/exocrine glands

abnormal ovary morphology ( J:61141 )

♀ • mice exhibit ovarian tubule hyperplasia

decreased secondary ovarian follicle number ( J:61141 )

♀ • number of pre-antral follicle cells is reduced compared to in wild-type mice

decreased tertiary ovarian follicle number ( J:61141 )

♀ • number of antral follicle cells is reduced compared to in wild-type mice

impaired ovarian folliculogenesis ( J:61141 )

♀ • follicle development is impaired at the cuboidal stages

♀ • however, some oocytes undergo maturation

ovary hyperplasia ( J:61141 )

♀

ovary cyst ( J:61141 )

♀

increased Leydig cell number ( J:61141 )

♂

Genotype
MGI:4358555

hm3

• Allelic Composition: Kit^tm1.1Bsm/Kit^tm1.1Bsm
• Genetic Background: involves: 129S1/Sv * C57BL/6J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:146561 )

N • mice exhibit a normal response a myelosuppressive dose of 5-fluorouracil treatment or treatment with phenylhydrazine

Genotype
MGI:4358485

ht4

• Allelic Composition: Kit^tm1.1Bsm/Kit^W
• Genetic Background: involves: 129S1/Sv * C57BL/6

pigmentation

abnormal ventral coat pigmentation ( J:90485 )

• dorsal depigmentation is worse than in Kit^W heterozygotes

integument

abnormal ventral coat pigmentation ( J:90485 )

• dorsal depigmentation is worse than in Kit^W heterozygotes

Genotype
MGI:4358484

cx5

• Allelic Composition: Il2rg^tm1Cgn/Il2rg^tm1Cgn; Kit^tm1.1Bsm/Kit^tm1.1Bsm
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

hematopoietic system

arrested T cell differentiation ( J:90485 )

♀ • similar to in Il2rg^tm1Cgn homozygotes, T cell development is blocked at the TN3 to TN4 stage

immune system

arrested T cell differentiation ( J:90485 )

♀ • similar to in Il2rg^tm1Cgn homozygotes, T cell development is blocked at the TN3 to TN4 stage