All Phenotypes Gabra1<tm1Rmck> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gabra1^tm1Rmck
targeted mutation 1, Ruth M McKernan
MGI:2177611

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabra1^tm1Rmck/Gabra1^tm1Rmck	involves: 129S7/SvEvBrd * BALB/c * C57BL/6	MGI:3832491

Allelic Composition	Gabra1^tm1Rmck/Gabra1^tm1Rmck
Genetic Background	involves: 129S7/SvEvBrd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra1^tm1Rmck mutation (0 available); any Gabra1 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

• diazepam-treated mice fail to exhibit impaired balance and coordination due to sedative effects as do similarly treated wild-type mice

• however, mice exhibit a normal myorelaxant response to diazepam

• locomotor activity is increased in diazepam-treated mice compared to in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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