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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gbx2+
wild type
MGI:2176807
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gbx2tm1Mrt/Gbx2+
Tg(Nes-cre)1Atp/? 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3687492
cx2
 		Gbx2tm1.1Mrt/Gbx2+
Fgf8tm1.4Mrt/Fgf8+ 		B6.129-Gbx2tm1.1Mrt Fgf8tm1.4Mrt MGI:3664073


Genotype
MGI:3687492
cn1
Allelic
Composition		 Gbx2tm1Mrt/Gbx2+
Tg(Nes-cre)1Atp/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1Mrt mutation (0 available); any Gbx2 mutation (27 available)
Tg(Nes-cre)1Atp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:111945 )
• mice are viable; cre expression is detected in adult brain and kidney (>99% recombination)




Genotype
MGI:3664073
cx2
Allelic
Composition		 Gbx2tm1.1Mrt/Gbx2+
Fgf8tm1.4Mrt/Fgf8+
Genetic
Background		 B6.129-Gbx2tm1.1Mrt Fgf8tm1.4Mrt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (25 available)
Gbx2tm1.1Mrt mutation (0 available); any Gbx2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal pharyngeal arch artery morphology ( J:100584 )
• ~16% of double heterozygotes exhibit PAA-related cardiovascular defects vs 0% in single Gbx2tm1Mrt or Fgf8tm1.4Mrt heterozygotes
• however, no incidences of a double outlet right ventricle, an overriding aorta or a retroesophageal right subclavian artery are observed
retroesophageal right subclavian artery ( J:100584 )
• 20% of double heterozygotes with cardiovascular defects display a retroesophageal right subclavian artery
right aortic arch ( J:100584 )
• 80% of double heterozygotes with cardiovascular defects exhibit a right aortic arch

craniofacial
abnormal pharyngeal arch artery morphology ( J:100584 )
• ~16% of double heterozygotes exhibit PAA-related cardiovascular defects vs 0% in single Gbx2tm1Mrt or Fgf8tm1.4Mrt heterozygotes
• however, no incidences of a double outlet right ventricle, an overriding aorta or a retroesophageal right subclavian artery are observed

embryo
abnormal pharyngeal arch artery morphology ( J:100584 )
• ~16% of double heterozygotes exhibit PAA-related cardiovascular defects vs 0% in single Gbx2tm1Mrt or Fgf8tm1.4Mrt heterozygotes
• however, no incidences of a double outlet right ventricle, an overriding aorta or a retroesophageal right subclavian artery are observed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory