Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation
(2 available);
any
Bdnf mutation
(41 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation
(2 available);
any
Bdnf mutation
(41 available)
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behavior/neurological
N |
• locomotor activity, anxiety, and novel object recognition responses in animals receiving injections of a lentivirus-cre (LV-cre) in the prelimbic cortex are similar to controls
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• animals receiving injections of a LV-cre in the prelimbic cortex display normal acquisition and expression of newly acquired fear, but when retested for fear to the cue (tone), show significantly decreased freezing responses relative to controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation
(2 available);
any
Bdnf mutation
(41 available)
Tg(Cck-cre)CKres mutation
(1 available)
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behavior/neurological
N |
• locomotor function, baseline startle response, pain sensitivity and prepulse inhibition are similar to controls
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• mice show robust attenuation of freezing when presented with the conditioned stimulus (tone) when tested for expression of previously learned fear
• mice show deficits in short- and long-term learning and memory to the conditioned cue, but display normal rate of extinction of conditioned fear
• 7,8-Dihydroxyflavone treatment rescues this impairment in cued fear conditioning
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mortality/aging
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• life span is shorter than in Mecp2 single homozygous mice
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behavior/neurological
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• dramatic reduction in wheel running activity at 4 weeks of age
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nervous system
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• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls
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mortality/aging
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• life span is shorter than in Mecp2 single hemizygous mice but longer than in mutant mice homozygous for the Bdnf allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation
(2 available);
any
Bdnf mutation
(41 available)
Tg(Camk2a-cre)159Kln mutation
(0 available)
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behavior/neurological
growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation
(2 available);
any
Bdnf mutation
(41 available)
Tg(Camk2a-cre)93Kln mutation
(1 available)
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behavior/neurological
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• food intake is 74% higher than in controls
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• display increased inter-male aggression
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• mutants by 4 weeks of age become agitated and active and appear stressed when handled
• mutants continue to appear agitated after the habituation period in a novel cage, with a 40% reduction in activity after an hour of habituation compared to 72% reduction in controls
• in a light/dark exploration test, mutants take 3.6 times longer to make the first transition from the dark to the light compartment, they spend half as much time in the light zone compared with controls and only make 35% the number of dark-to-light zone transitions compared to controls
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• hyperactive when stressed
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growth/size/body
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• increased body weight is seen at 8 weeks of age and by 30 weeks, males and females are 80 and 150% heavier than controls, respectively
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• 10% increase in naso-anal length compared with controls
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homeostasis/metabolism
reproductive system
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• sterility in obese females but not younger lean females, indicating that sterility is secondary to the effect of obesity
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nervous system
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• decreased size of CA2 neurons
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• decreased size of the olfactory glomeruli
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation
(2 available);
any
Bdnf mutation
(41 available)
Tg(Syn1-cre)671Jxm mutation
(1 available)
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behavior/neurological
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• an increased number of stimulations are required to initiate kindling behavior, however once initiated progression through subsequent classes of kindling is the same as in wild-type mice and no increase in the current required to induce the initial electrographic seizure is seen
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nervous system
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• an increased number of stimulations are required to initiate kindling behavior, however once initiated progression through subsequent classes of kindling is the same as in wild-type mice and no increase in the current required to induce the initial electrographic seizure is seen
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behavior/neurological
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• no response is seen to the antidepressant desipramine in mutants when doxycycline treatment is stopped at 3 months of age
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• contextual learning is impaired in mutants when doxycycline treatment is stopped at 3 months of age compared to mutant littermates maintained on doxycycline
• contextual learning is virtually absent in mutants when no doxycycline treatment is given throughout development
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• cued learning is normal in mutants when doxycycline treatment is stopped at 3 months of age but impaired when no doxycycline treatment is given throughout development
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• mutants bred without doxycycline treatment are hyperactive compared to mutants bred with doxycycline treatment
• hyperactivity is not seen when doxycycline treatment is stopped at 3 months of a
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nervous system
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• long term potentiation is impaired requiring a greater amplitude stimulus to evoke any response in mutants when doxycycline treatment is stopped at 3 months of age compared to mutant littermates maintained on doxycycline
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