Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Runx2)Flng mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Ihhtm1Amc mutation
(1 available);
any
Ihh mutation
(22 available)
Tg(Col2a1-cre)3Amc mutation
(0 available)
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skeleton
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• the nonhypertrophic chondrocyte zone in the tibia is reduced to a greater extent than in Ihhtm1Amc homozygotes
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• hypertrophic chondrocytes exhibit accelerated progression from early stage to late stage hypertrophy compared with control mice
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cellular
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Tg(Col2a1-cre)3Amc mutation
(0 available)
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skeleton
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• at E18.5, no identifiable bone matrix is observed in long bones
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Gli2*)Flng mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Ihhtm1Amc mutation
(1 available);
any
Ihh mutation
(22 available)
Tg(Col2a1-cre)3Amc mutation
(0 available)
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mortality/aging
skeleton
N |
• vascularization and bone formation in the diaphysis are normal
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• similar to in Ihhtm1Amc homozygotes, orthotopic osteoblast differentiation is impaired as determined by marker expression
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• at E15.5 and E18.5, the proliferative zone is slightly larger than in Ihhtm1Amc homozygotes but smaller than in wild-type mice
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• vascularization of the hypertrophic zone is improved compared to in Ihhtm1Amc homozygotes
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• columnar organization of chondrocytes is partially restored compared to in Ihhtm1Amc homozygotes but is still disorganized compared to in wild-type mice
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• at E18.5, mice fail to exhibit bone deposition in the perichondrium flanking the hypertrophic regions where the bone collar normally forms in the long bones of wild-type mice
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cellular
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• similar to in Ihhtm1Amc homozygotes, orthotopic osteoblast differentiation is impaired as determined by marker expression
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Xt-J mutation
(3 available);
any
Gli3 mutation
(80 available)
Gt(ROSA)26Sortm2(Gli2*)Flng mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Ihhtm1Amc mutation
(1 available);
any
Ihh mutation
(22 available)
Tg(Col2a1-cre)3Amc mutation
(0 available)
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mortality/aging
skeleton
N |
• unlike in Ihhtm1Amc Gli3Xt-J homozygotes the marrow cavity and hypertrophic chondrocyte are normal
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• the growth region cartilage is longer than in wild-type mice
• the columnar zone contains areas of disorganization unlike in wild-type mice
• however, orthotopic bone collar formation is normal unlike in Ihhtm1Amc homozygotes
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growth/size/body
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• while larger than Ihhtm1Amc homozygotes at E18.5, mice are smaller than wild-type mice
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limbs/digits/tail
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• while larger than in Ihhtm1Amc homozygotes at E18.5, limbs are shorter than in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Runx2)Flng mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Runx2tm1Mjo mutation
(0 available);
any
Runx2 mutation
(42 available)
Tg(Col2a1-cre)3Amc mutation
(0 available)
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skeleton
N |
• unlike Runx2tm1Mjo homozygotes, mice exhibit normal cartilage, bone collar, and marrow and restored osteoblast differentiation and cartilage hypertrophy
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• at E18.5, bone formation defects observed in Runx2tm1Mjo homozygotes are partially recovered in the endochondrial skeleton but not the skull
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(Runx2)Flng mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Runx2tm1Mjo mutation
(0 available);
any
Runx2 mutation
(42 available)
Tg(Col2a1-cre)3Amc mutation
(0 available)
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skeleton
N |
• unlike Runx2tm1Mjo homozygotes, mice exhibit normal bone collar
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• like Runx2tm1Mjo homozygotes, mice lack a marrow cavity
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• at E18.5, bone formation defects observed in Runx2tm1Mjo homozygotes are partially recovered in the endochondrial skeleton but not the skull
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm1Amc mutation
(1 available);
any
Smo mutation
(39 available)
Smotm2Amc mutation
(1 available);
any
Smo mutation
(39 available)
Tg(Col2a1-cre)3Amc mutation
(0 available)
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skeleton
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• shorter long bones, more severe than in mutants carrying Tg(Col2a1-cre)15Amc but less severe than in mutants carrying Tg(Col2a1-cre)10Amc
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Gli2*)Flng mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Col2a1-cre)3Amc mutation
(0 available)
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skeleton
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• as determined by marker expression, cartilage growth in long bones is reduced due to premature onset of hypertrophy compared with wild-type mice
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• decreased at E14.5 and E18.5
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growth/size/body