Phenotypes associated with this allele
immune system
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• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased memory precursors and memory CD8+ T cells compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
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• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice
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• from CD8+ effector T cells following infection with actA- L. monocytogenes-expressing ovalbumin
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hematopoietic system
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• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased memory precursors and memory CD8+ T cells compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
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• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice
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immune system
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• mutants infected with lymphocytic choriomeningitis virus (LCMV) to induce T-cell activation and thus cre-expression exhibit better survival of effector CD8 T cells under serum-starvation conditions compared to controls, but only show modest effects on the expansion and contraction of effector CD8 T cells
• clonal burst of mutant effector CD8 T cells is about 1/2 that of wild-type controls and there is a slight, but not significant reduction in the number of memory T cells that form in lymphoid and nonlymphoid tissues
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• production of IL-2 by CD8 T cells is diminished in mutants infected with LCMV to induce T-cell activation and thus cre-expression
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hematopoietic system
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• mutants infected with lymphocytic choriomeningitis virus (LCMV) to induce T-cell activation and thus cre-expression exhibit better survival of effector CD8 T cells under serum-starvation conditions compared to controls, but only show modest effects on the expansion and contraction of effector CD8 T cells
• clonal burst of mutant effector CD8 T cells is about 1/2 that of wild-type controls and there is a slight, but not significant reduction in the number of memory T cells that form in lymphoid and nonlymphoid tissues
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immune system
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• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
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• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice
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hematopoietic system
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• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
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• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Ach mutation
(0 available);
any
Fas mutation
(82 available)
Tg(GZMB-cre)1Jcb mutation
(2 available)
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immune system
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• CD3+B220+ double positive cells accumulate
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hematopoietic system
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• CD3+B220+ double positive cells accumulate
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Analysis Tools