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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Sycp1-cre)4Min
transgene insertion 4, Minoo Rassoulzadegan
MGI:2176068
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Artm1Chc/Y
Tg(Sycp1-cre)4Min/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3775036
cn2
 		Thratm1Ffla/Thra+
Tg(Sycp1-cre)4Min/? 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:3758926


Genotype
MGI:3775036
cn1
Allelic
Composition		 Artm1Chc/Y
Tg(Sycp1-cre)4Min/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Chc mutation (0 available); any Ar mutation (22 available)
Tg(Sycp1-cre)4Min mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:118270 )
N
• sperm counts are similar to those in wild-type males
• males are fertile; meiosis and spermatogenesis are unaffected
• testes are normal in size and morphology; serum testosterone levels are within normal range




Genotype
MGI:3758926
cn2
Allelic
Composition		 Thratm1Ffla/Thra+
Tg(Sycp1-cre)4Min/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sycp1-cre)4Min mutation (1 available)
Thratm1Ffla mutation (0 available); any Thra mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:125353 )
• 48% of mice do not reach adulthood

reproductive system
female infertility ( J:125353 )
• despite no obvious defects in ovary morphology, females are sterile

nervous system
abnormal cerebellum external granule cell layer morphology ( J:125353 )
• unlike in wild-type mice, at P21 the external granule layer persists and granular precursor cells are still present
abnormal Purkinje cell dendrite morphology ( J:125353 )
• at P15, arborization of Purkinje cell dendrites is reduced by number and size of dendritic spines

behavior/neurological
ataxia ( J:125353 )
• mice display an ataxic bearing and spread their hindlimbs to maintain their posture

growth/size/body
disproportionate dwarf ( J:125353 )
• while surviving mice gain weight they suffer from a permanent and disproportioned dwarfism
postnatal growth retardation ( J:125353 )

homeostasis/metabolism
impaired adaptive thermogenesis ( J:125353 )
• mice exhibit a defect in thermogenesis such that the body temperature in some mice drops within a few hours after cold exposure

cardiovascular system
increased heart rate ( J:125353 )
• 224+/-24 beats per minute compared to 393+/-45 beats per minute in wild-type mice
irregular heartbeat ( J:125353 )
• mice sometime display cardiac arrhythmia

skeleton
delayed endochondral bone ossification ( J:125353 )
• ossification of the long bones is delayed

hematopoietic system
decreased spleen weight ( J:125353 )
• at P15, spleen weight is decreased (26.9+/-12.2 mg compared to 39.5+/-9.1 mg in wild-type mice)

vision/eye
delayed eyelid opening ( J:125353 )
• eyelid opening was delayed to P25 compared to P15 in wild-type mice

immune system
decreased spleen weight ( J:125353 )
• at P15, spleen weight is decreased (26.9+/-12.2 mg compared to 39.5+/-9.1 mg in wild-type mice)




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory